Trapping Tribbles: Nanobody-assisted structure of the TRIB2 pseudokinase

被引：1

作者：

Santana, Frederick R. ^{[1
]}

Linossi, Edmond M. ^{[1
]}

Jura, Natalia ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94158 USA

来源：

STRUCTURE | 2022年 / 30卷 / 11期

基金：

美国国家卫生研究院;

关键词：

MECHANISM;

D O I：

10.1016/j.str.2022.10.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TRIB2, a member of the human Tribbles pseudokinase family, functions as a molecular scaffold in diverse signaling pathways. In this issue of Structure, Jamieson et al. report the first high-resolution structure of TRIB2 bound to a nanobody that offers insights into its "active-like'' state.

引用

页码：1465 / 1467

页数：3