Multimodal image-guided enzyme/prodrug cancer therapy

被引：46

作者：

Li, Cong ^{[1
]}

Winnard, Paul T., Jr. ^{[1
]}

Takagi, Tomoyo ^{[1
]}

Artemov, Dmitri ^{[1
]}

Bhujwalla, Zaver M. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, JHU ICMIC Program, Baltimore, MD 21205 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 47期

关键词：

MAGNETIC-RESONANCE-SPECTROSCOPY; COLI CYTOSINE DEAMINASE; 5-FLUOROURACIL; PERMEABILITY; MUTAGENESIS; ACTIVATION; TUMORS;

D O I：

10.1021/ja066199i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The conjugate of bacterial cytosine deaminase (bCD) and poly-l-lysine (PLL) that was functionalized with biotin, rhodamine, and Gd3+-DOTA was synthesized and characterized. It demonstrated high relaxivity, improved enzymatic specificity to prodrug 5-fluorocytosine, low cytotoxicity, efficient cell uptake, and high enzymatic stability in fresh mouse serum and human breast cancer cell culture. Copyright © 2006 American Chemical Society.

引用

页码：15072 / 15073

页数：2

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