Multimodal image-guided enzyme/prodrug cancer therapy

被引：46
|
作者：
Li, Cong [1 ]
Winnard, Paul T., Jr. [1 ]
Takagi, Tomoyo [1 ]
Artemov, Dmitri [1 ]
Bhujwalla, Zaver M. [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, JHU ICMIC Program, Baltimore, MD 21205 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 47期
关键词：
MAGNETIC-RESONANCE-SPECTROSCOPY; COLI CYTOSINE DEAMINASE; 5-FLUOROURACIL; PERMEABILITY; MUTAGENESIS; ACTIVATION; TUMORS;
D O I：
10.1021/ja066199i
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The conjugate of bacterial cytosine deaminase (bCD) and poly-l-lysine (PLL) that was functionalized with biotin, rhodamine, and Gd3+-DOTA was synthesized and characterized. It demonstrated high relaxivity, improved enzymatic specificity to prodrug 5-fluorocytosine, low cytotoxicity, efficient cell uptake, and high enzymatic stability in fresh mouse serum and human breast cancer cell culture. Copyright © 2006 American Chemical Society.
引用
收藏
页码：15072 / 15073
页数：2
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