Synthesis and Biological Evaluation of New 4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine Derivatives

被引：2
|
作者：
Prezent, Mikhail A. [1 ]
Baranin, Sergey, V [1 ]
机构：
[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prospect, Moscow 119991, Russia
来源：
CHEMISTRYSELECT | 2020年 / 5卷 / 44期
关键词：
antioxidants; heterocycles; 4; 5; 6; 7-tetrahydro-1H-imidazo[4; 5-c]pyridines; Suzuki reaction; radical-scavenging activity; ANTIOXIDANT; INHIBITORS; KINASE;
D O I：
10.1002/slct.202003440
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A number of new spinaceamine derivatives have been synthesized by the Suzuki reaction of 5-Boc-2-iodo-spinaciamine with aryl or heteryl boronic acids. The obtained compounds exhibited a varying degree of ABTS radical-scavenging activity, and some of them found to be more effective radical-scavengers comparing with spinacine. Both spinacine and its synthesized derivatives do not inhibit cholinesterases and carboxylesterase.
引用
收藏
页码：14017 / 14020
页数：4
相关论文
共 50 条
  • [41] A NEW SYNTHESIS OF IMIDAZO[4,5-C][1,3]DIAZEPINE
    IVANOV, EI
    POLISHCHUK, AA
    MAZEPA, AV
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1992, (09): : 1193 - 1195
  • [42] DIRECT SUBSTITUTION OF A NITROGROUP BY HALOGEN IN IMIDAZO[4,5-C]PYRIDINE DERIVATIVES SERIES
    YUTILOV, YM
    SVERTILO.IA
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1974, (06): : 854 - 855
  • [43] New polyfunctional imidazo[4,5-C]pyridine motifs: Synthesis, crystal studies, docking studies and antimicrobial evaluation
    Jose, Gilish
    Kumara, T. H. Suresha
    Nagendrappa, Gopalpur
    Sowmya, H. B. V.
    Jasinski, Jerry P.
    Millikan, Sean P.
    Chandrika, N.
    More, Sunil S.
    Harish, B. G.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 77 : 288 - 297
  • [44] Synthesis and Biological Activities of Novel 1H-Imidazo[4,5-b]pyridine Derivatives
    Jebamani, Jesurajan
    Praneshm, Shubha Jayachamarajapura
    Shivalingappa, Jayadev
    Narayanarao, Manjunatha
    Pasha, Mussuvir
    Pawar, Chandrakant
    CHEMISTRYSELECT, 2023, 8 (28):
  • [45] Synthesis of a novel series of imidazo[4,5-c]pyrazole derivatives and their evaluation as herbicidal agents
    Vicentini, CB
    Manfrini, M
    Mazzanti, M
    Scatturin, A
    Romagnoli, C
    Mares, D
    ARCHIV DER PHARMAZIE, 1999, 332 (10) : 337 - 342
  • [46] Synthesis of some new 2-(substituted-phenyl)imidazo[4,5-c] and [4,5-b]pyridine derivatives and their antimicrobial activities
    Altaib, Moftah
    Doganc, Fatima
    Kaskatepe, Banu
    Goker, Hakan
    MOLECULAR DIVERSITY, 2024, 28 (05) : 2817 - 2829
  • [47] Synthesis of new imidazo[4,5-b]pyridine derivatives
    Bukowski, L
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 2002, (07): : 937 - 944
  • [48] NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A SERIES OF NOVEL 4,5-DIHYDRO-4-OXO-3H-IMIDAZO[4,5-C]PYRIDINE DERIVATIVES
    MEDERSKI, WWKR
    DORSCH, D
    BOKEL, HH
    BEIER, N
    LUES, I
    SCHELLING, P
    JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (11) : 1632 - 1645
  • [49] SYNTHESIS OF SOME NEW IMIDAZO[4,5-B]PYRIDINE DERIVATIVES USING 2-CYANOMETHYL-1-METHYL-1H-IMIDAZO[4,5-B]PYRIDINE
    Bukowski, L.
    Zwolska, Zofia
    Augustynowicz-Kopec, Ewa
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2012, 187 (07) : 879 - 887
  • [50] SYNTHESIS OF 6-SUBSTITUTED IMIDAZO[4,5-C]PYRAZOLE-5-THIONES
    VICENTINI, CB
    FERRETTI, V
    VERONESE, AC
    GUARNERI, M
    MANFRINI, M
    GIORI, P
    HETEROCYCLES, 1995, 41 (03) : 497 - 506
12345