Nonmetal Catalyzed Hydrogenation of Carbonyl Compounds

被引：205
|
作者：
Scott, Daniel J. [1 ]
Fuchter, Matthew J. [1 ]
Ashley, Andrew E. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 45期
基金：
英国工程与自然科学研究理事会;
关键词：
HOMOGENEOUS HYDROGENATION; METAL; HYDROSILATION; ACTIVATION; MECHANISM; ACIDITY; ETHERS;
D O I：
10.1021/ja5088979
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Solutions of the Lewis acid B(C6F5)(3) in 1,4-dioxane are found to effectively catalyze the hydrogenation of a variety of ketones and aldehydes. These reactions, the first to allow entirely metal-free catalytic hydrogenation of carbonyl groups under relatively mild reaction conditions, are found to proceed via a frustrated Lewis pair mechanism in which the solvent, a weak Bronsted base yet moderately strong donor, plays a pivotal role.
引用
收藏
页码：15813 / 15816
页数：4
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