Immunoglobulin therapy for plasma cell-rich rejection in the renal allograft

被引：27
|
作者：
Adrogue, Horacio E.
Soltero, Lihana
Land, Geoffrey A.
Ramanathan, Venkataraman
Truong, Luan D.
Suki, Wadi N.
机构：
[1] Methodist Hosp, Baylor Coll Med, Nephrol Sect, Houston, TX 77030 USA
[2] Methodist Hosp, Dept Pathol, Houston, TX 77030 USA
[3] Baylor Coll Med, Houston, TX 77030 USA
[4] Kidney Inst, Houston, TX USA
来源：
TRANSPLANTATION | 2006年 / 82卷 / 04期
关键词：
humoral rejection; antibodies; plasmapheresis; graft loss; intravenous immunoglobulin;
D O I：
10.1097/01.tp.0000231922.11453.ec
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Plasma cell-rich acute rejection (PCAR) is associated with poor allograft outcome in renal transplantation. Previous studies report a graft half-life of six months after a single PCAR episode. However, the management of this condition is unclear. Intravenous immunoglobulin (IVIG) therapy, by virtue of its immunomodulating properties, and its influence on B-cell maturation into plasma cells, may be a good candidate for reversing this type of rejection. We report four episodes of PCAR in two patients who responded well to IVIG with improvement in renal function.
引用
收藏
页码：567 / 569
页数：3
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