Decreased Level of Albumin in Peripheral Blood Mononuclear Cells of Streptozotocin-Induced Diabetic Rats

被引：14
|
作者：
Park, Ki Tae [1 ]
Yun, Chul-Ho [1 ]
Bae, Chun-Sik [2 ]
Ahn, Taeho [2 ]
机构：
[1] Chonnam Natl Univ, Sch Biol Sci & Technol, Kwangju 500757, South Korea
[2] Chonnam Natl Univ, Coll Vet Med, Kwangju 500757, South Korea
来源：
JOURNAL OF VETERINARY MEDICAL SCIENCE | 2014年 / 76卷 / 08期
关键词：
albumin; diabetes; expression; oxidative stress; streptozotocin; OXIDATIVE STRESS; RADICAL PRODUCTION; URINARY ALBUMIN; EXPRESSION; SERUM; MELLITUS; TISSUES; PROTEIN;
D O I：
10.1292/jvms.13-0631
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
We investigated the phenotypic level of albumin in peripheral blood mononuclear cells (PBMC) of streptozotocin (STZ)-induced diabetic rats. A specific reduction of albumin was identified by 2-dimensional electrophoresis and mass spectrometry. Decreased albumin content was also confirmed by immunoblotting and quantitative real-time PCR. Since albumin is a major and predominant antioxidant in plasma, the PBMC albumin may also contribute to their antioxidant activity. By measuring the amount of H2O2, lipid peroxidation and the redox form of glutathione, it was found that the production of the oxidative stress was elevated in STZ-diabetic rats compared to that of normal control. We suggest, therefore, that decreased albumin content may lead to the decreased antioxidant activity in the PBMC of type 1 diabetic rats.
引用
收藏
页码：1087 / 1092
页数：6
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