Too Much, Too Little or Just Enough: A Goldilocks Effect for IL-13 and Skin Barrier Regulation?

被引：14

作者：

Strid, Jessica ^{[1
]}

McLean, W. H. Irwin ^{[2
]}

Irvine, Alan D. ^{[3
,4
,5
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Div Immunol & Inflammat, Dept Med, London, England

[2] Univ Dundee, Sch Life Sci, Dept Dermatol & Genet Med, Dundee, Scotland

[3] Our Ladys Childrens Hosp Crumlin, Natl Childrens Res Ctr, Dublin, Ireland

[4] Our Ladys Childrens Hosp Crumlin, Dept Paediat Dermatol, Dublin, Ireland

[5] Univ Dublin Trinity Coll, Dept Clin Med, Dublin 2, Ireland

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2016年 / 136卷 / 03期

基金：

英国医学研究理事会;

关键词：

FILAGGRIN; RECEPTOR; IL-13R-ALPHA-2; EXPRESSION; PROTEINS; ISOFORMS;

D O I：

10.1016/j.jid.2015.12.025

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The mechanistic relationship between IL-4/IL-13 and skin barrier function has been of interest since the filaggrin discovery and the subsequent in vitro demonstration that IL-4 and IL-13 downregulate filaggrin expression in cultured keratinocytes. Honzke and colleagues explore these interactions further. The effects of IL-4/IL-13 may be context dependent, with differing roles in homeostasis and in disease.

引用

页码：561 / 564

页数：4

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