Too Much, Too Little or Just Enough: A Goldilocks Effect for IL-13 and Skin Barrier Regulation?

被引：14

作者：

Strid, Jessica ^{[1
]}

McLean, W. H. Irwin ^{[2
]}

Irvine, Alan D. ^{[3
,4
,5
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Div Immunol & Inflammat, Dept Med, London, England

[2] Univ Dundee, Sch Life Sci, Dept Dermatol & Genet Med, Dundee, Scotland

[3] Our Ladys Childrens Hosp Crumlin, Natl Childrens Res Ctr, Dublin, Ireland

[4] Our Ladys Childrens Hosp Crumlin, Dept Paediat Dermatol, Dublin, Ireland

[5] Univ Dublin Trinity Coll, Dept Clin Med, Dublin 2, Ireland

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2016年 / 136卷 / 03期

基金：

英国医学研究理事会;

关键词：

FILAGGRIN; RECEPTOR; IL-13R-ALPHA-2; EXPRESSION; PROTEINS; ISOFORMS;

D O I：

10.1016/j.jid.2015.12.025

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The mechanistic relationship between IL-4/IL-13 and skin barrier function has been of interest since the filaggrin discovery and the subsequent in vitro demonstration that IL-4 and IL-13 downregulate filaggrin expression in cultured keratinocytes. Honzke and colleagues explore these interactions further. The effects of IL-4/IL-13 may be context dependent, with differing roles in homeostasis and in disease.

引用

页码：561 / 564

页数：4

共 50 条

[1] Too little, too much or just right? Goldilocks revisited...
Sharma, Rahul
Henry, Timothy D.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 2018, 91 (05) : 840 - 841
[2] The Goldilocks Effect in Naval Ship Design: Too Little, Too Much, Just Right
Keane, Robert G.
Tibbitts, Barry F.
NAVAL ENGINEERS JOURNAL, 2022, 134 (04) : 39 - 56
[3] Teaching Goldilocks to Supervise: Not Too Much, Not Too Little, but Just Right
Ling, Louis J.
ACADEMIC EMERGENCY MEDICINE, 2013, 20 (09) : 950 - 951
[4] Goldilocks calcium concentrations and the regulation of oxidative phosphorylation: Too much, too little, or just right
Vilas-Boas, Eloisa A.
Cabral-Costa, Joao Victor
Ramos, Vitor M.
da Silva, Camille C. Caldeira
Kowaltowski, Alicia J.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2023, 299 (03)
[5] Vitamin D and the Goldilocks Principle: Too Little, Too Much, or Just Right?
Drake, Matthew T.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2014, 99 (04): : 1164 - 1166
[6] The "Goldilocks model" of overtime in construction: not too much, not too little, but just right
Goldenhar, LM
Hecker, S
Moir, S
Rosecrance, J
JOURNAL OF SAFETY RESEARCH, 2003, 34 (02) : 215 - 226
[7] Afterword Trust: Too much, too little, never just enough
Ballestero, Andrea
CAMBRIDGE JOURNAL OF ANTHROPOLOGY, 2023, 41 (02): : 105 - 111
[8] The Goldilocks Oxygen Principle: not too little and not too much
Will R. Flanigan
Isha H. Jain
Nature Cardiovascular Research, 2022, 1 : 1101 - 1103
[9] Follicle stimulating hormone: the Goldilocks hormone, too little, too much, just right
Santoro, Nanette
FERTILITY AND STERILITY, 2023, 119 (02) : 165 - 165
[10] The Goldilocks Quandary of Health Care Resources Too Little, Too Much, or Just Right?
Morgan, Daniel M.
Main, Elliott
Gee, Rebekah E.
OBSTETRICS AND GYNECOLOGY, 2016, 127 (06): : 1039 - 1044

← 1 2 3 4 5 →