Forkhead box protein 3 (FoxP3) mRNA as a diagnostic marker in ovarian tumors: a pilot study

被引：0
|
作者：
Abdel-Hay, N. H. [1 ]
Mansour, A. A. [1 ]
El Sherbini, M. A. [1 ]
Motaleb, F. I. Abdel [1 ]
El-Shalakany, A. H. [2 ]
机构：
[1] Ain Shams Univ, Med Biochem & Mol Biol Dept, Fac Med, Ramsis St, Cairo 11381, Abbasia, Egypt
[2] Ain Shams Univ, Gynecol Oncol Unit, Matern Hosp, Cairo, Abbasia, Egypt
来源：
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY | 2017年 / 38卷 / 02期
关键词：
Ovarian tumor; q-RT-PCR; FoxP3; mRNA; CA125; T-reg; REGULATORY T-CELLS; RISK; SUBPOPULATIONS; EXPRESSION; PROGNOSIS; CA125;
D O I：
10.12892/ejgo3470.2017
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose: To assess the diagnostic performance of forkhead box protein 3 (FoxP3) mRNA in ovarian tumors. Materials and Methods: Using quantitative real time reverse transcription PCR (q-RT-PCR), FoxP3 mRNA level was measured in fresh frozen ovarian tumors and its diagnostic performance was compared to those of preoperative serum CA125 and risk of malignancy index (RMI). Results: FoxP3 mRNA was differentially expressed in the malignant (n = 25) and benign (n = 25) groups, yet without statistically significant differences; positivity rate: 15/25 vs. 10/25; p = 0.157, median: 0.429 vs. 0.046; p = 0.684, and mean +/- SD: 73.75 +/- 234.68 vs. 247.09 +/- 792.17; p = 0.301. Although it showed much less diagnostic performance (AUC: 0.534), FoxP3 mRNA enhanced the diagnostic sensitivity and specificity of both CA125 and RMI (96% and 100%, for both). Conclusion: FoxP3 mRNA may not be good diagnostic marker in ovarian tumors; however it may prove valuable in defining underlying tumor molecular signature.
引用
收藏
页码：251 / 256
页数：6
相关论文
共 50 条
  • [11] The expression of the Forkhead Box Transcription Factor FoxP3 is associated with poor prognosis in melanoma
    Knol, A. C.
    Nguyen, J. M.
    Khammari, A.
    Quereux, G.
    Brocard, A.
    Dreno, B.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 (10) : 2521 - 2521
  • [12] Association of Human forkhead box protein 3 (FOXP3) gene polymorphisms with idiopathic recurrent pregnancy loss among Kazakhstani women
    Abdukassimova, Meruyert
    Kanabekova, Perizat
    Bauyrzhanova, Zhansaya
    Ukybassova, Talshyn
    Kaldygulova, Lyazzat
    Imankulova, Balkenzhe
    Aimagambetova, Gulzhanat
    Almawi, Wassim Y.
    GENE, 2021, 801
  • [13] DNA hypermethylation of Forkhead box protein 3 (FOXP3) locus leads to quantitative defects of regulatory T cells in systemic sclerosis
    Wang, Yaoyao
    Shu, Ye
    Wang, Qing
    Zhao, Ming
    Liang, Gongping
    Lu, Qianjin
    Xiao, Rong
    ARTHRITIS AND RHEUMATISM, 2013, 65 : S285 - S285
  • [14] DNA hypermethylation of the forkhead box protein 3 (FOXP3) promoter in CD4+T cells of patients with systemic sclerosis
    Wang, Y. Y.
    Wang, Q.
    Sun, X. H.
    Liu, R. Z.
    Shu, Y.
    Kanekura, T.
    Huang, J. H.
    Li, Y. P.
    Wang, J. C.
    Zhao, M.
    Lu, Q. J.
    Xiao, R.
    BRITISH JOURNAL OF DERMATOLOGY, 2014, 171 (01) : 39 - 47
  • [15] Transforming growth factor β1 (TGF-β1) and Forkhead Box Protein 3 (FOXP3) genes polymorphisms in allergic rhinitis
    Ghaffari, J.
    Abediankenari, S.
    Hassannia, H.
    Ghaffari, J.
    ALLERGY, 2012, 67 : 113 - 113
  • [16] Effects of Maternal Allergy On Umbilical Cord Blood Regulatory T Cell Forkhead Box Protein 3 (FOXP3) DNA Methylation
    North, Michelle
    Mah, Sarah
    Steacy, Lisa
    Brook, Jeffrey
    Kobor, Michael
    Ellis, Anne K.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 131 (02) : AB53 - AB53
  • [17] Study of the association of forkhead box P3 (FOXP3) gene polymorphisms with unexplained recurrent spontaneous abortions in Indian population
    Mishra, Shivani
    Srivastava, Anukool
    Mandal, Kausik
    Phadke, Shubha R.
    JOURNAL OF GENETICS, 2018, 97 (02) : 405 - 410
  • [18] Deep sequencing of the TCR- repertoire of human forkhead box protein 3 (FoxP3)+ and FoxP3- T cells suggests that they are completely distinct and non-overlapping
    Golding, A.
    Darko, S.
    Wylie, W. H.
    Douek, D. C.
    Shevach, E. M.
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2017, 188 (01): : 12 - 21
  • [19] Forkhead box protein 3 (FOXP3) controls the activation, expansion and clonal contraction of autoreactive T cells independently of their selected states in the thymus
    Gao, JX
    Chang, X
    Chen, L
    Wen, J
    Zhang, HM
    Godfrey, VL
    Zheng, P
    FASEB JOURNAL, 2005, 19 (04): : A340 - A340
  • [20] Transcription Factor Forkhead Box Protein 3 (FOXP3) as a Prognostic Indicator for Postoperative Outcomes in Patients with Breast Cancer: Establishment of a Prognostic Nomogram
    Tan, Chunlei
    Xu, Jinling
    Zhang, Shiyuan
    Liu, Shuqiang
    Yang, Xiaotian
    Wu, Danping
    Yu, Boqian
    Huang, Yuanxi
    BREAST CANCER-TARGETS AND THERAPY, 2024, 16
12345