Forkhead box protein 3 (FoxP3) mRNA as a diagnostic marker in ovarian tumors: a pilot study

被引：0
|
作者：
Abdel-Hay, N. H. [1 ]
Mansour, A. A. [1 ]
El Sherbini, M. A. [1 ]
Motaleb, F. I. Abdel [1 ]
El-Shalakany, A. H. [2 ]
机构：
[1] Ain Shams Univ, Med Biochem & Mol Biol Dept, Fac Med, Ramsis St, Cairo 11381, Abbasia, Egypt
[2] Ain Shams Univ, Gynecol Oncol Unit, Matern Hosp, Cairo, Abbasia, Egypt
来源：
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY | 2017年 / 38卷 / 02期
关键词：
Ovarian tumor; q-RT-PCR; FoxP3; mRNA; CA125; T-reg; REGULATORY T-CELLS; RISK; SUBPOPULATIONS; EXPRESSION; PROGNOSIS; CA125;
D O I：
10.12892/ejgo3470.2017
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose: To assess the diagnostic performance of forkhead box protein 3 (FoxP3) mRNA in ovarian tumors. Materials and Methods: Using quantitative real time reverse transcription PCR (q-RT-PCR), FoxP3 mRNA level was measured in fresh frozen ovarian tumors and its diagnostic performance was compared to those of preoperative serum CA125 and risk of malignancy index (RMI). Results: FoxP3 mRNA was differentially expressed in the malignant (n = 25) and benign (n = 25) groups, yet without statistically significant differences; positivity rate: 15/25 vs. 10/25; p = 0.157, median: 0.429 vs. 0.046; p = 0.684, and mean +/- SD: 73.75 +/- 234.68 vs. 247.09 +/- 792.17; p = 0.301. Although it showed much less diagnostic performance (AUC: 0.534), FoxP3 mRNA enhanced the diagnostic sensitivity and specificity of both CA125 and RMI (96% and 100%, for both). Conclusion: FoxP3 mRNA may not be good diagnostic marker in ovarian tumors; however it may prove valuable in defining underlying tumor molecular signature.
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页码：251 / 256
页数：6
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