Synthesis of new dehydro 2-azatryptophans and derivatives via Heck cross-coupling reactions of 3-iodoindazoles with methyl 2-(acetylamino)acrylate

被引：29
|
作者：
Crestey, Francois [1 ]
Collot, Valerie [1 ]
Stiebing, Silvia [1 ]
Rault, Sylvain [1 ]
机构：
[1] Univ Caen, CERMN, UPRES, EA3915,UFR Sci Pharmaceut, F-14032 Caen, France
来源：
SYNTHESIS-STUTTGART | 2006年 / 20期
关键词：
dehydro; 2-azatryptophans; protective amino acid derivatives; catalytic hydrogenation; Heck cross-coupling reaction; 3-iodoindazoles; 2-(acetylamino)acrylate;
D O I：
10.1055/s-2006-950242
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This paper describes the Heck cross-coupling reaction of 3-iodoindazoles with methyl 2-(acetylamino)acrylate as a general route to new dehydro 2-azatryptophans and protected amino acid derivatives after catalytic hydrogenation.
引用
收藏
页码：3506 / 3514
页数：9
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