Upstairs, downstairs: spatial regulation of Hippo signalling

被引：53

作者：

Fulford, Alexander ^{[1
]}

Tapon, Nicolas ^{[2
]}

Ribeiro, Paulo S. ^{[1
]}

机构：

[1] Queen Mary Univ London, Barts Canc Inst, Ctr Tumour Biol, Charterhouse Sq, London EC1M 6BQ, England

[2] Francis Crick Inst, 1 Midland Rd, London NW1 1AT, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2018年 / 51卷

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

TUMOR-SUPPRESSOR PATHWAY; AMPK-MEDIATED REGULATION; BASAL CELL POLARITY; TISSUE-GROWTH; F-ACTIN; NUCLEAR-LOCALIZATION; CONTACT INHIBITION; DROSOPHILA HOMOLOG; UBIQUITIN LIGASE; EPITHELIAL-CELLS;

D O I：

10.1016/j.ceb.2017.10.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cellular signalling lies at the heart of every decision involved in the development and homeostasis of multicellular organisms. The Hippo pathway was discovered nearly two decades ago through seminal work in Drosophila and rapidly emerged as a crucial signalling network implicated in developmental and oncogenic growth, tissue regeneration and stem cell biology. Here, we review recent advances in the field relating to the upstream regulation of Hippo signalling and the intracellular tug-of-war that tightly controls its main target, the transcriptional co-activator Yorkie/YAP.

引用

页码：22 / 32

页数：11

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