Preclinical characterization of GSK532, a novel STING agonist with potent anti-tumor activity

被引：10

作者：

Yang, Jingsong ^{[1
]}

Adam, Michael ^{[1
]}

Clemens, Jim ^{[1
]}

Creech, Katrina ^{[1
]}

Schneck, Jess ^{[1
]}

Pasikanti, Kishore ^{[1
]}

Jean-Luc Tran ^{[1
]}

Joglekar, Devika ^{[1
]}

Hopson, Chris ^{[1
]}

Pesiridis, Scott ^{[1
]}

Ramanjulu, Joshi ^{[1
]}

Lian, Yiqian ^{[1
]}

Adams, Jerry L. ^{[1
]}

Smothers, James ^{[1
]}

Hoos, Axel ^{[1
]}

机构：

[1] GlaxoSmithKline, Collegeville, PA USA

来源：

CANCER RESEARCH | 2018年 / 78卷 / 13期

关键词：

D O I：

10.1158/1538-7445.AM2018-5554

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

5554

引用

页数：2

共 50 条

[21] Preclinical Studies of a Novel Anti-Tumor Prodrug Therapy
Wang, Jing-Hung
Zhao, Ming
Barak, Yoram
Hoffman, Robert M.
Matin, A. C.
MOLECULAR THERAPY, 2009, 17 : S109 - S109
[22] In vivo programmed myeloid cells expressing novel chimeric antigen receptors show potent anti-tumor activity in preclinical solid tumor models
Argueta, Shannon
Wang, Yuxiao
Zhao, Hongyun
Diwanji, Neha
Gorgievski, Michael
Cochran, Edward
Grudzien-Nogalska, Ewa
D'Alessandro, Josephine
Mccreedy, Bruce
Prod'homme, Thomas
Hofmeister, Robert
Ding, Jian
Getts, Daniel
FRONTIERS IN IMMUNOLOGY, 2024, 15
[23] The combination of a STING agonist with cytokines results in robust anti-tumor effects in autochthonous tumor models
Blaj, Cristina
Li, Yingjoy
Chen, Allen
Descien, Anthony
Francica, Brian
McWhirter, Sarah
Picton, Lora
Garcia, K. Christopher
Raulet, David
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
[24] SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis
Song, Chunying
Liu, Dong
Liu, Suxing
Li, Di
Horecny, Ivana
Zhang, Xinzhu
Li, Puhui
Chen, Lei
Miller, Matthew
Chowdhury, Rasheduzzaman
Issa, Mena
Shen, Ru
Yan, Yinfa
Zhang, Fengqi
Zhang, Lei
Zhang, Limin
Bai, Chang
Feng, Jun
Zhuang, Linghang
Zhang, Rumin
Li, Jing
Wilkinson, Hilary
Liu, Jian
Tao, Weikang
SCIENTIFIC REPORTS, 2022, 12 (01)
[25] A highly selective and potent TLR8 agonist ZG0895 in preclinical studies of anti-tumor activities
Cui, Dawei
Liu, Ruifeng
Yang, Huanyi
Zhu, Bing
Sheng, Zelin
Lv, Binhua
CANCER RESEARCH, 2023, 83 (07)
[26] SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis
Chunying Song
Dong Liu
Suxing Liu
Di Li
Ivana Horecny
Xinzhu Zhang
Puhui Li
Lei Chen
Matthew Miller
Rasheduzzaman Chowdhury
Mena Issa
Ru Shen
Yinfa Yan
Fengqi Zhang
Lei Zhang
Limin Zhang
Chang Bai
Jun Feng
Linghang Zhuang
Rumin Zhang
Jing Li
Hilary Wilkinson
Jian Liu
Weikang Tao
Scientific Reports, 12
[27] STING agonist cGAMP enhances anti-tumor activity of CAR-NK cells against pancreatic cancer
Da, Yanyan
Liu, Yuxia
Hu, Yuan
Liu, Wenzeng
Ma, Junpeng
Lu, Nan
Zhang, Chengsheng
Zhang, Cai
ONCOIMMUNOLOGY, 2022, 11 (01):
[28] JNJ-'6196: A next generation STING agonist with potent preclinical activity by the IV route
Chan, Szeman Ruby
Bignan, Gilles
Pierson, Emily
Mahady, Sally
Ta, Hayley
Schepens, Wim
Thuring, Jan Willem
Lim, Heng Keang
Otieno, Monicah
Wilde, Thomas
Singer, Monica
Bogdan, Nancy
Patel, Shefali
Luistro, Leo
Campion, Liam
Smith, Melissa
Wiley, Diana
Packman, Kathryn
Allegrezza, Michael
Morgan, Caitlin
Sendecki, Jocelyn
Van Aller, Glenn
Krosky, Daniel
Connolly, Peter
Edwards, James
Staquet, Kim
Emanuel, Stuart L.
CANCER RESEARCH, 2020, 80 (16)
[29] Novel anti-tumor activity of targeted LSD1 inhibition by GSK2879552
Mohammad, H.
Smitheman, K.
Van Aller, G.
Cusan, M.
Kamat, S.
Liu, Y.
Johnson, N.
Hann, C.
Armstrong, S.
Kruger, R.
EUROPEAN JOURNAL OF CANCER, 2014, 50 : 72 - 72
[30] STING activation in the tumor microenvironment with a synthetic human STING-activating cyclic dinucleotide leads to potent anti-tumor immunity
Glickman, Laura Hix
Kanne, David B.
Kasibhatla, Shailaja
Li, Jie
Pferdekamper, AnneMarie Culazzo
Gauthier, Kelsey Sivick
Deng, Weiwen
Desbien, Anthony L.
Katibah, George E.
Leong, Justin J.
Sung, Leonard
Metchette, Ken
Ndubaku, Chudi
Zheng, Lianxing
Cho, Charles
Feng, Yan
McKenna, Jeffrey M.
Tallarico, John A.
Bender, Steven L.
Dubensky, Thomas W.
McWhirter, Sarah M.
CANCER RESEARCH, 2016, 76

← 1 2 3 4 5 →