Statins and Risk of New-Onset Diabetes Mellitus: is there a Rationale for Individualized Statin Therapy?

被引:25
|
作者
Navarese, Eliano Pio [1 ]
Szczesniak, Anna [1 ]
Kolodziejczak, Michalina [1 ]
Gorny, Bartosz [1 ]
Kubica, Jacek [1 ]
Suryapranata, Harry [2 ]
机构
[1] Nicolaus Copernicus Univ, Ludwik Rydygier Coll Med, Dept Cardiol & Internal Med, PL-8094 Bydgoszcz, Poland
[2] Radboud Univ Nijmegen Med Ctr, Dept Cardiol, Nijmegen, Netherlands
关键词
CAUSES INSULIN-RESISTANCE; BETA-CELL LINE; ANIMAL-MODEL; PRAVASTATIN; ATORVASTATIN; ADIPONECTIN; SIMVASTATIN; CORONARY; METAANALYSIS; CHOLESTEROL;
D O I
10.1007/s40256-013-0053-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Statins (hydroxymethylglutaryl-coenzyme-A reductase inhibitors) are first-line agents for the management of hyperlipidemia in patients at high risk of cardiovascular (CV) events, and are the most commonly prescribed CV drugs worldwide. Although safe and generally well tolerated, there is growing evidence to suggest that statins are associated with an elevated occurrence of new-onset diabetes mellitus (DM). Recent experimental and clinical data have prompted the US Food and Drug Administration to add information to statin labels regarding the increased risk of development of type 2 DM. The main purpose of this review is to critically discuss the clinical evidence regarding the association of statin use with new-onset DM, the CV benefit/risk ratio with statins, and the rationale for individualized statin therapy.
引用
收藏
页码:79 / 87
页数:9
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