Pre-Clinical Studies of Anti-CD123 CAR-T Cells for the Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

被引：11
|
作者：
Cai, Tianyu [1 ]
Galetto, Roman [2 ]
Gouble, Agnes [2 ]
Smith, Julianne [2 ]
Cavazos, Antonio [1 ]
Konoplev, Sergej [3 ]
Lane, Andrew A. [4 ]
Guzman, Monica L. [5 ]
Kantarjian, Hagop M. [1 ]
Pemmaraju, Naveen [1 ]
Konopleva, Marina [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX USA
[2] Cellectis SA, Paris, France
[3] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX USA
[4] Dana Farber Canc Inst, Boston, MA USA
[5] Weill Cornell Med Coll, Div Hematol & Med Oncol, Dept Med, New York, NY USA
来源：
BLOOD | 2016年 / 128卷 / 22期
关键词：
D O I：
10.1182/blood.V128.22.4039.4039
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
4039
引用
收藏
页数：5
相关论文
共 50 条
  • [41] Efficacy Proof of Concept for Allogeneic CD123 Targeting CAR T-Cells Against Primary Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): Efficient Control of Tumor Progression in PDX Model and Potential Loss of CD123 Expression in Relapsed Disease
    Cai, Tianyu
    Black, Kathryn L.
    Naqvi, Ammar S.
    Taylor, Deanne
    Zhao, Ming
    Yuan, Qi
    Sugita, Mayumi
    Galetto, Roman
    Gouble, Agnes
    Smith, Julianne N. P.
    Cavazos, Antonio
    Han, Lina
    Zhang, Qi
    Kuruvilla, Vinitha Mary
    Ma, Helen
    Konoplev, Sergej
    Tang, Guilin
    Gu, Jun
    Su, Xiaoping
    Neelapu, Sattva S.
    Lane, Andrew A.
    Kantarjian, Hagop M.
    Guzman, Monica L.
    Pemmaraju, Naveen
    Thomas-Tikhonenko, Andrei
    Konopleva, Marina Y.
    BLOOD, 2019, 134
  • [42] Treatment of rare cutaneous T-cell lymphoma and blastic plasmacytoid dendritic cell neoplasm
    Wehkamp, U.
    Weichenthal, M.
    HAUTARZT, 2017, 68 (09): : 711 - 715
  • [43] Breakthrough in Blastic Plasmacytoid Dendritic Cell Neoplasm Cancer Therapy Owing to Precision Targeting of CD123
    Zanotta, Serena
    Galati, Domenico
    De Filippi, Rosaria
    Pinto, Antonio
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (03)
  • [44] Anti-CD38 Monoclonal Antibody Daratuzumab Improve Responses to Chemotherapy-Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): A Case Report
    Li, Xiaoqing
    An, Gang
    Du, Xin
    Chen, Weihong
    BLOOD, 2020, 136
  • [45] Immunotherapies Targeting CD123 and CD303: A New Frontier in Treating Blastic Plasmacytoid Dendritic Cell Neoplasm
    Galati, Domenico
    Zanotta, Serena
    Florio, Fabrizia
    Mele, Sara
    De Filippi, Rosaria
    Pinto, Antonio
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 26 (06)
  • [46] CD38 and BCL2 expression guides treatment with daratumumab and venetoclax in tagraxofusp-refractory blastic plasmacytoid dendritic cell neoplasm (BPDCN) featuring dynamic loss of CD123
    Hu, Xiaoyi
    Ediriwickrema, Asiri
    Saleem, Atif
    Tan, Brent
    Pemmaraju, Naveen
    Mannis, Gabriel N.
    LEUKEMIA RESEARCH, 2024, 139
  • [47] BPDCN: When polychemotherapy does not compromise allogeneic CD123 CAR-T cell cytotoxicity
    Poussard, Margaux
    Philippe, Laure
    Fredon, Maxime
    Bole-Richard, Elodie
    Biichle, Sabeha
    Renosi, Florian
    Perrin, Sophie
    Kroemer, Marie
    Limat, Samuel
    Bonnefoy, Francis
    Daguindau, Etienne
    Deconinck, Eric
    Gruson, Berengere
    Saas, Philippe
    Adotevi, Olivier
    Garnache-Ottou, Francine
    Angelot-Delettre, Fanny
    EJHAEM, 2021, 2 (01): : 128 - 133
  • [48] Experience with IMGN632, a Novel CD123-Targeting Antibody-Drug Conjugate (ADC), in Frontline Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
    Pemmaraju, Naveen
    Martinelli, Giovanni
    Todisco, Elisabetta
    Lane, Andrew A.
    Acuna-Cruz, Evelyn
    Deconinck, Eric
    Wang, Eunice S.
    Sweet, Kendra
    Rizzieri, David A.
    Marconi, Giovanni
    Mazzarella, Luca
    DeAngelo, Daniel J.
    Montesinos, Pau
    Gigli, Federica
    Erba, Harry P.
    Konopleva, Marina
    Kantarjian, Hagop
    Walter, Roland B.
    Aribi, Ahmed
    Lebon, Delphine
    Levy, Moshe Y.
    Sloss, Callum M.
    Malcolm, Kara E.
    Zweidler-McKay, Patrick A.
    Daver, Naval
    BLOOD, 2021, 138
  • [49] Clinical diversity and treatment approaches to blastic plasmacytoid dendritic cell neoplasm: a retrospective multicentre study
    Bruggen, M-C.
    Valencak, J.
    Stranzenbach, R.
    Li, N.
    Stadler, R.
    Jonak, C.
    Bauer, W.
    Porkert, S.
    Blaschke, A.
    Meiss, F.
    Nicolay, J. P.
    Wehkamp, U.
    Schlaak, M.
    Nguyen, V. A.
    Romani, N.
    Cozzio, A.
    Gayathri, N.
    Dimitriou, F.
    French, L. E.
    Dummer, R.
    Guenova, E.
    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2020, 34 (07) : 1489 - 1495
  • [50] Clinical diversity and treatment approaches to blastic plasmacytoid dendritic cell neoplasm: a retrospective multicenter study
    Bruggen, Marie-Charlotte
    Valencak, Julia
    Stranzenbach, Rene
    Stadler, Rudolf
    Jonak, Constanze
    Bauer, Wolfgang
    Porkert, Stefanie
    Blaschke, Amelie
    Meiss, Frank
    Nicolay, Jan
    Wehkamp, Ulrike
    Schlaak, Max
    Van Anh Nguyen
    Romani, Nikolaus
    Cozzio, Antonio
    Gayathri, Nair
    Li, Nick
    French, Lars
    Dummer, Reinhard
    Guenova, Emmanuella
    EUROPEAN JOURNAL OF CANCER, 2019, 119 : S33 - S33
12345