Honokiol Suppresses Renal Cancer Cells' Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling

被引：50
|
作者：
Li, Weidong [1 ]
Wang, Qian [2 ]
Su, Qiaozhen [3 ]
Ma, Dandan [4 ]
An, Chang [3 ]
Ma, Lei [1 ]
Liang, Hongfeng [3 ]
机构：
[1] Guangzhou Med Univ, CCGMU, Affiliated Canc Hosp, Dept Med Oncol, Guangzhou, Guangdong, Peoples R China
[2] Jinan Univ, Fac Med, Guangzhou, Guangdong, Peoples R China
[3] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Neurol, Guangzhou, Guangdong, Peoples R China
[4] Guangzhou Univ Chinese Med, Internal Med Tradit Chinese Med, Guangzhou, Guangdong, Peoples R China
来源：
MOLECULES AND CELLS | 2014年 / 37卷 / 05期
关键词：
cancer stem cell; epithelial-mesenchymal transition; honokiol; microRNA; renal cell carcinoma; ANTICANCER AGENTS; INVASION ASSAYS; CARCINOMA; MICRORNAS; PATHWAYS; COMBINATION; MIGRATION; TARGETS; MIR-124; GLIOMA;
D O I：
10.14348/molcells.2014.0009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Renal cell carcinoma (RCC) is associated with a high frequency of metastasis and only few therapies substantially prolong survival. Honokiol, isolated from Magnolia spp. bark, has been shown to exhibit pleiotropic anticancer effects in many cancer types. However, whether honokiol could suppress RCC metastasis has not been fully elucidated. In the present study, we found that honokiol suppressed renal cancer cells' metastasis via dual-blocking epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) properties. In addition, honokiol inhibited tumor growth in vivo. It was found that honokiol could up-regulate miR-141, which targeted ZEB2 and modulated ZEB2 expression. Honokiol reversed EMT and suppressed CSC properties partly through the miR-141/ZEB2 axis. Our study suggested that honokiol may be a suitable therapeutic strategy for RCC treatment.
引用
收藏
页码：383 / 388
页数：6
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