Multicenter Study on the Long-Term (3-Year) Efficacy of Lanthanum Carbonate in Dialysis Patients

被引：0

作者：

Ando, Ryoichi ^{[1
]}

Yama, Satomi ^{[1
]}

Ohnishi, Tsuyoshi ^{[1
]}

Iwamoto, Shunsuke ^{[1
]}

Kimura, Hitoshi ^{[1
]}

Chida, Yoshiko ^{[2
]}

Ishida, Yuji ^{[3
]}

Yamada, Kouei ^{[4
]}

Inagaki, Yuichiro ^{[4
]}

Takayama, Masanobu ^{[5
]}

Tachibana, Ken ^{[6
]}

Kikuchi, Kan ^{[7
]}

Inoue, Atsushi ^{[7
]}

Ohtsuka, Masakazu ^{[8
]}

机构：

[1] Musashino Red Cross Hosp, Dept Nephrol, Tokyo, Japan

[2] Nakano Clin, Tokyo, Japan

[3] Kyonan Clin, Tokyo, Japan

[4] Kichijoji Ekimae Clin, Tokyo, Japan

[5] Takayama Clin, Tokyo, Japan

[6] Tachibana Clin, Tokyo, Japan

[7] Shimo Ochiai Clin, Tokyo, Japan

[8] Tokiwa Clin, Toride, Ibaraki, Japan

来源：

THERAPEUTIC APHERESIS AND DIALYSIS | 2014年 / 18卷

关键词：

Lanthanum Carbonate; Long-Term Effects; Management Target Values; Multicenter Study; CHRONIC KIDNEY-DISEASE; MORTALITY RISK; SERUM-CALCIUM; HEMODIALYSIS-PATIENTS; PHOSPHATE; HYPERPHOSPHATEMIA; PTH;

D O I：

10.1111/1744-9987.12206

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We previously conducted a multicenter study enrolling 101 dialysis patients with hyperphosphatemia in which lanthanum carbonate (LC) was administered for 2 years. In this study, the administration has been continued for an additional year, and we have evaluated the long-term (a total of 3 years) effects of LC. The average serum phosphorus (P) level was 6.05 mg/dL at the start and decreased to 5.84 mg/dL after 3 years, but no significant differences were observed at both points. The average serum corrected calcium (Ca) level significantly reduced after 3 years (P < 0.001). As results of evaluating the achievement rates with the management target values of serum P, Ca and intact parathyroid hormone (PTH) stated in the Japanese guideline, the achievement rates increased after 3 years. From these results, LC is considered to be a useful P binder that can be used for long-term treatment of hyperphosphatemia, without causing a Ca load.

引用

页码：2 / 8

页数：7

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