Sleep deprivation increases brain serotonin turnover in the rat

被引：55
|
作者：
Asikainen, M [1 ]
Toppila, J [1 ]
Alanko, L [1 ]
Ward, DJ [1 ]
Stenberg, D [1 ]
PorkkaHeiskanen, T [1 ]
机构：
[1] UNIV HELSINKI, INST BIOMED, FIN-00014 HELSINKI, FINLAND
来源：
NEUROREPORT | 1997年 / 8卷 / 07期
关键词：
5-hydroxyindoleacetic acid (5-HIAA); 5-hydroxytryptophan (5-HT); rat; serotonin; sleep; sleep deprivation;
D O I：
10.1097/00001756-199705060-00006
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
IN order to study possible time-dependent changes in serotonin metabolism in rat brain, male Wistar rats were subjected to 3, 6 or 12 h total sleep deprivation (SD) by gentle handling. In addition two groups of rats subjected first to 6 h SD were allowed 2 or 4 h rebound sleep. Tissue concentrations of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were measured from several brain areas using HPLC/ECD. SD significantly increased the 5-HIAA/5-HT ratio in frontal cortex, hippocampus, hypothalamus and brain stem, indicating increased 5-HT turnover in those areas. After 2 and 4h rebound sleep, the 5-HIAA/5-HT ratio was similar to that in controls. We conclude that a short SD increases 5-HT turnover in the rat brain for the duration of SD only.
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页码：1577 / 1582
页数：6
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