Sleep deprivation increases brain serotonin turnover in the rat

被引：55
|
作者：
Asikainen, M [1 ]
Toppila, J [1 ]
Alanko, L [1 ]
Ward, DJ [1 ]
Stenberg, D [1 ]
PorkkaHeiskanen, T [1 ]
机构：
[1] UNIV HELSINKI, INST BIOMED, FIN-00014 HELSINKI, FINLAND
来源：
NEUROREPORT | 1997年 / 8卷 / 07期
关键词：
5-hydroxyindoleacetic acid (5-HIAA); 5-hydroxytryptophan (5-HT); rat; serotonin; sleep; sleep deprivation;
D O I：
10.1097/00001756-199705060-00006
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
IN order to study possible time-dependent changes in serotonin metabolism in rat brain, male Wistar rats were subjected to 3, 6 or 12 h total sleep deprivation (SD) by gentle handling. In addition two groups of rats subjected first to 6 h SD were allowed 2 or 4 h rebound sleep. Tissue concentrations of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were measured from several brain areas using HPLC/ECD. SD significantly increased the 5-HIAA/5-HT ratio in frontal cortex, hippocampus, hypothalamus and brain stem, indicating increased 5-HT turnover in those areas. After 2 and 4h rebound sleep, the 5-HIAA/5-HT ratio was similar to that in controls. We conclude that a short SD increases 5-HT turnover in the rat brain for the duration of SD only.
引用
收藏
页码：1577 / 1582
页数：6
相关论文
共 50 条
  • [1] SLEEP-DEPRIVATION INCREASES BRAIN-SEROTONIN TURNOVER IN THE DJUNGARIAN HAMSTER
    ASIKAINEN, M
    DEBOER, T
    PORKKAHEISKANEN, T
    STENBERG, D
    TOBLER, I
    [J]. NEUROSCIENCE LETTERS, 1995, 198 (01) : 21 - 24
  • [2] Total sleep deprivation increases extracellular serotonin in the rat hippocampus
    Lopez-Rodriguez, F
    Wilson, CL
    Maidment, NT
    Poland, RE
    Engel, J
    [J]. NEUROSCIENCE, 2003, 121 (02) : 523 - 530
  • [3] Serotonin turnover in discrete regions of young rat brain after 24 h REM sleep deprivation
    Senthilvelan, M
    Ravindran, R
    Samson, J
    Devi, RS
    [J]. NEUROCHEMICAL RESEARCH, 2006, 31 (01) : 81 - 84
  • [4] Serotonin Turnover in Discrete Regions of Young Rat Brain After 24 h REM Sleep Deprivation
    M. Senthilvelan
    R. Ravindran
    J. Samson
    R. Shella Devi
    [J]. Neurochemical Research, 2006, 31 : 81 - 84
  • [5] EFFECT OF SLEEP-DEPRIVATION ON BRAIN-SEROTONIN IN THE RAT
    BORBELY, AA
    STEIGRAD, P
    TOBLER, I
    [J]. BEHAVIOURAL BRAIN RESEARCH, 1980, 1 (02) : 205 - 210
  • [6] Serotonin turnover in different duration of sleep recovery in discrete regions of young rat brain after 24 h REM sleep deprivation
    Senthilvelan, M.
    Ravindran, R.
    Samson, J.
    Devi, R. Sheela
    [J]. BRAIN & DEVELOPMENT, 2006, 28 (08): : 526 - 528
  • [7] Sleep deprivation prior to stroke increases sleep and attenuates brain lesion in the rat
    Cam, E.
    Gao, B.
    Imbach, L.
    Hodor, A.
    Bassetti, C.
    [J]. JOURNAL OF SLEEP RESEARCH, 2012, 21 : 196 - 196
  • [8] BRAIN NOREPINEPHRINE AND SEROTONIN LEVELS FOLLOWING REM SLEEP DEPRIVATION IN RAT
    STERN, WC
    MILLER, FP
    COX, RH
    MAICKEL, RP
    [J]. PSYCHOPHARMACOLOGIA, 1971, 22 (01): : 50 - &
  • [9] STIMULATION OF BRAIN-SEROTONIN TURNOVER BY PARADOXICAL SLEEP-DEPRIVATION IN INTACT AND HYPOPHYSECTOMIZED RATS
    CRAMER, H
    TAGLIAMO.A
    TAGLIAMO.P
    PEREZCRU.J
    GESSA, GL
    [J]. BRAIN RESEARCH, 1973, 54 (MAY17) : 372 - 375
  • [10] Distinct effects of sleep deprivation on binding to norepinephrine and serotonin transporters in rat brain
    Hipólide, DC
    Moreira, KM
    Barlow, KBL
    Wilson, AA
    Nobrega, JN
    Tufik, S
    [J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2005, 29 (02): : 297 - 303
12345