Surface Plasmon Resonance Phase-Sensitive Imaging (SPR-PI) Sensor Based on a Novel Prism Phase Modulator

被引：7
|
作者：
Ye, Gaoao [1 ]
Yang, Wei [1 ]
Jiang, Li [1 ]
He, Sailing [1 ]
机构：
[1] Zhejiang Univ, Zhejiang Prov Key Lab Sensing Technol, JORCEP Joint Res Ctr Photon Royal Inst Technol Sw, Ctr Opt & Electromagnet Res, Hangzhou 310058, Zhejiang, Peoples R China
来源：
PROGRESS IN ELECTROMAGNETICS RESEARCH-PIER | 2014年 / 145卷
基金：
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词：
D O I：
10.2528/PIER14030402
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
A novel prism phase modulator (PPM) for phase difference modulation between p- and s-polarization lights in a surface plasmon resonance phase-sensitive imaging sensor is proposed in this paper. The PPM consists of a rhombic prism (to obtain a curve of phase difference between the two polarizations), a rotation stage and a mirror. The PPM shows great modulation stability and helps to achieve a high detection resolution. Surface plasmon resonance phase imaging is realized with a microfluidic device and a CCD camera. Experimental result shows that the detection resolution of our SPR-PI sensor based on phase-interrogation method is 7.61 x 10(-7) RIU with hydrous samples, which is 16 times improved compared with that based on intensity-interrogation. Real-time monitoring of the interaction between Angiogenin and anti-Angiogenin is also illustrated.
引用
收藏
页码：309 / 318
页数：10
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