Involvement of Y-family DNA polymerases in mutagenesis caused by oxidized nucleotides in Escherichia coli

被引：40
|
作者：
Yamada, Masami
Nunoshiba, Tatsuo
Shimizu, Masatomi
Gruz, Petr
Kamiya, Hiroyuki
Harashima, Hideyoshi
Nohmi, Takehiko
机构：
[1] Natl Inst Hlth Sci, Div Genet & Mutagenesis, Setagaya Ku, Tokyo 1588501, Japan
[2] Tohoku Univ, Grad Sch Life Sci, Aoba Ku, Sendai, Miyagi 9808577, Japan
[3] Tokyo Healthcare Univ, Setagaya Ku, Tokyo 1548568, Japan
[4] Hokkaido Univ, Grad Sch Pharmaceut Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan
来源：
JOURNAL OF BACTERIOLOGY | 2006年 / 188卷 / 13期
关键词：
D O I：
10.1128/JB.00281-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Escherichia coli DNA polymerase IV incorporated 2-hydroxy-dATP opposite template guanine or thymine and 8-hydroxy-dGTP exclusively opposite adenine in vitro. Mutator phenotypes in sod/fur strains were substantially diminished by deletion of dinB and/or umuDC. DNA polymerases IV and V may be involved in mutagenesis caused by incorporation of the oxidized deoxynucleoside triphosphates.
引用
收藏
页码：4992 / 4995
页数：4
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