Allelic variants of PRNP in 16 Chinese local sheep breeds

被引：8

作者：

Lan, Zouran ^{[1
,2
]}

Li, Jinming ^{[1
]}

Sun, Chengyou ^{[1
]}

Liu, Yutian ^{[1
]}

Zhao, Yonggang ^{[1
]}

Chi, Tianying ^{[1
]}

Yu, Xiaojing ^{[1
]}

Song, Fangfang ^{[1
]}

Wang, Zhiliang ^{[1
]}

机构：

[1] China Anim Hlth & Epidemiol Ctr, Qingdao 266032, Shandong, Peoples R China

[2] Shandong Ctr Anim Dis Control & Prevent, Jinan 266003, Peoples R China

来源：

ARCHIVES OF VIROLOGY | 2014年 / 159卷 / 08期

关键词：

PRION PROTEIN GENE; NATURAL SCRAPIE; PRP GENE; BRITISH SHEEP; SUFFOLK SHEEP; CLOSED FLOCK; POLYMORPHISMS; GENOTYPE; OVINE; SUSCEPTIBILITY;

D O I：

10.1007/s00705-014-2048-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Here, polymorphisms of the ovine prion protein gene were analyzed in 486 Chinese sheep from 16 main local breeds. Polymorphisms R or H at codons 154 and four polymorphisms at codon 171 encoding Q, R, H, or K were identified. The A/V polymorphism at codon 136 was not observed, and all sheep were homozygous for A at this position. In addition, ten polymorphisms at codons 21, 101, 112, 127, 138, 141, 143, 146, 153 and 189 were detected. The predominant Q allele occurred at codon 171, with a high frequency of 88.68 %, implying a risk of scrapie in China.

引用

页码：2141 / 2144

页数：4

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