Vitamin D and its analogs as anticancer and anti-inflammatory agents

被引：44
|
作者：
Chen, Jingxuan [1 ]
Tang, Ziyu [1 ]
Slominski, Andrzej T. [2 ]
Li, Wei [3 ]
Zmijewski, Michal A. [4 ]
Liu, Yao [5 ]
Chen, Jianjun [1 ]
机构：
[1] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Peoples R China
[2] Univ Alabama Birmingham, Dept Dermatol, Birmingham, AL 35294 USA
[3] Univ Tennessee, Hlth Sci Ctr, Dept Pharmaceut Sci, Memphis, TN 38163 USA
[4] Med Univ Gdansk, Dept Histol, 1a Debinki, PL-80211 Gdansk, Poland
[5] Shanghai Jiao Tong Univ, Instrumental Anal Ctr, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2020年 / 207卷
关键词：
Vitamin D analogs; Vitamin D receptor; Anticancer; Anti-inflammatory; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3 ANALOGS; BREAST-CANCER CELLS; D-RECEPTOR LIGANDS; PROSTATE-CANCER; BIOLOGICAL EVALUATION; SIDE-CHAIN; NUCLEAR RECEPTOR; GENE-EXPRESSION; HEMODIALYSIS-PATIENTS; PANCREATIC-CANCER;
D O I：
10.1016/j.ejmech.2020.112738
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Vitamin D3 is the precursor of the steroid hormone calcitriol (1 alpha,25-dihydroxyvitamin D3), a potent agonist of the transcription factor vitamin D receptor (VDR). Calcitriol has received large appreciation due to the impact not only on mineral homeostasis, but also on metabolic diseases, immunological disorders, and cancer. A supraphysiological dose of calcitriol is required to reduce the proliferation of cancer cells. However, the dose will lead to calcemic side effects such as hypercalcemia and hypercalciuria. Although several analogs of 1 alpha,25(OH)2D3 have shown potent anticancer or anti-inflammatory activity on cell cultures or in animal models, few vitamin D analogs have been successfully applied in the treatment of cancer or inflammatory diseases. This review will present and discuss vitamin D analogs that have the potential to be used as anticancer or anti-inflammatory agents. (C) 2020 Elsevier Masson SAS. All rights reserved.
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页数：17
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