Transient neutropenia in normal donors after G-CSF mobilization and stem cell apheresis

被引：26

作者：

Anderlini, P ^{[1
]}

Przepiorka, D ^{[1
]}

Seong, D ^{[1
]}

Champlin, R ^{[1
]}

Korbling, M ^{[1
]}

机构：

[1] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT HEMATOL,SECT BLOOD & MARROW TRANSPLANTAT,HOUSTON,TX 77030

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1996年 / 94卷 / 01期

关键词：

neutropenia; peripheral blood stem cell mobilization; granulocyte colony-stimulating factor; normal donors; allogeneic blood stem cell transplantation;

D O I：

10.1046/j.1365-2141.1996.d01-1778.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thirteen normal adult donors underwent daily leukapheresis for peripheral blood progenitor cell collection for allografting beginning on day 4 or 5 of G-CSF mobilization (12 mu g/kg/d). They had complete blood counts performed 7-10 d after the completion of the procedure. A reduction in the total leucocyte count below baseline levels, accounted for by a decrease in the absolute neutrophil (ANC) and lymphocyte counts, was noted. Neutropenia (ANC < 1 . 5 x 10(9)/l) occurred in two (15%) of the donors, The lowest ANC observed was 0 . 6 x 10(9)/l, The neutropenia was asymptomatic and resolved on follow-up evaluation.

引用

页码：155 / 158

页数：4

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