Transient neutropenia in normal donors after G-CSF mobilization and stem cell apheresis

被引：26
|
作者：
Anderlini, P [1 ]
Przepiorka, D [1 ]
Seong, D [1 ]
Champlin, R [1 ]
Korbling, M [1 ]
机构：
[1] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT HEMATOL,SECT BLOOD & MARROW TRANSPLANTAT,HOUSTON,TX 77030
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 1996年 / 94卷 / 01期
关键词：
neutropenia; peripheral blood stem cell mobilization; granulocyte colony-stimulating factor; normal donors; allogeneic blood stem cell transplantation;
D O I：
10.1046/j.1365-2141.1996.d01-1778.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Thirteen normal adult donors underwent daily leukapheresis for peripheral blood progenitor cell collection for allografting beginning on day 4 or 5 of G-CSF mobilization (12 mu g/kg/d). They had complete blood counts performed 7-10 d after the completion of the procedure. A reduction in the total leucocyte count below baseline levels, accounted for by a decrease in the absolute neutrophil (ANC) and lymphocyte counts, was noted. Neutropenia (ANC < 1 . 5 x 10(9)/l) occurred in two (15%) of the donors, The lowest ANC observed was 0 . 6 x 10(9)/l, The neutropenia was asymptomatic and resolved on follow-up evaluation.
引用
收藏
页码：155 / 158
页数：4
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