Development of an Active Site Peptide Analog of α-Fetoprotein That Prevents Breast Cancer

被引：11

作者：

Jacobson, Herbert I. ^{[1
,3
]}

Andersen, Thomas T. ^{[2
]}

Bennett, James A. ^{[3
]}

机构：

[1] Albany Med Coll, Dept Obstet & Gynecol, Albany, NY 12208 USA

[2] Albany Med Coll, Ctr Cardiovasc Sci, Albany, NY 12208 USA

[3] Albany Med Coll, Ctr Immunol & Microbial Dis, Albany, NY 12208 USA

来源：

CANCER PREVENTION RESEARCH | 2014年 / 7卷 / 06期

关键词：

ESTROGEN-SENSITIVE CELLS; MAMMARY-TUMOR CELLS; GROWTH-INHIBITION; MATERNAL SERUM; SECRETING HEPATOMA; MULTIPLE BIRTHS; PROBABLE ROLE; TWIN BIRTHS; RISK; RATS;

D O I：

10.1158/1940-6207.CAPR-13-0405

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epidemiologic studies associate elevated maternal serum levels of alpha-fetoprotein (AFP) with reduced breast cancer risk for parous women. Laboratory studies demonstrate direct anti-breast cancer activity of AFP. Here, we review the development of a small cyclic peptide that is an active site analog of AFP, referred to as AFPep, which is composed exclusively of amino acids, is orally active, has no discernable toxicity, and is effective for the treatment and prevention of breast cancer in animal models. (C)2014 AACR.

引用

页码：565 / 573

页数：9

共 50 条

[31] Expression of the alpha-fetoprotein gene in human breast cancer
Esteban, C
Terrier, P
Frayssinet, C
Uriel, J
TUMOR BIOLOGY, 1996, 17 (05) : 299 - 305
[32] HYDROLYSIS OF DEXTRANSUCRASE WITH LABELED ACTIVE-SITE PEPTIDE
DIETLIN, T
MOOSER, G
JOURNAL OF DENTAL RESEARCH, 1984, 63 : 262 - 262
[33] COVALENT LABELING OF ACTIVE SITE OF ANTIBODY WITH BROMOACETYLATED PEPTIDE
MIKORYAK, CA
LAWSON, WB
BROWN, RK
FEDERATION PROCEEDINGS, 1968, 27 (02) : 683 - &
[34] A FLUORESCENT PEPTIDE MODEL FOR THE THIOREDOXIN ACTIVE-SITE
KISHORE, R
MATHEW, MK
BALARAM, P
FEBS LETTERS, 1983, 159 (1-2) : 221 - 224
[35] ON ACTIVE SITE OF PROTEASES .3. MAPPING ACTIVE SITE OF PAPAIN - SPECIFIC PEPTIDE INHIBITORS OF PAPAIN
SCHECHTER, I
BERGER, A
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1968, 32 (05) : 898 - +
[36] STUDIES ON ACTIVE-SITE PEPTIDE ANALOGS OF BACTERIORHODOPSIN
ENGELHARD, M
HESS, B
HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1982, 363 (06): : 542 - 542
[37] ACTIVE SITE PEPTIDE FROM PEPSIN-C
KAY, J
RYLE, AP
BIOCHEMICAL JOURNAL, 1971, 123 (01) : 75 - &
[38] IDENTIFICATION OF AN ACTIVE-SITE PEPTIDE OF THE GASTRIC ATPASE
SACCOMANI, G
JACKSON, RJ
MUKIDJAM, E
BIOPHYSICAL JOURNAL, 1984, 45 (02) : A251 - A251
[39] Selection and characterization of a novel affibody peptide and its application in a two-site ELISA for the detection of cancer biomarker alpha-fetoprotein
Liu, Juanjuan
Cui, Dongxu
Jiang, Yi
Li, Yuyin
Liu, Zhenxing
Tao, Li
Zhao, Qing
Diao, Aipo
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 166 : 884 - 892
[40] Therapeutically cooperative and mechanistically distinct effects of an alpha-fetoprotein-derived peptide (AFPep) in combination with tamoxifen in models of breast cancer
Bennett, James A.
Defreest, Lori
Narendran, Amithi
Georgekutty, Justin
Lemanski, Nicole
Jacobson, Herbert I.
Andersen, Thomas T.
CANCER RESEARCH, 2006, 66 (08)

← 1 2 3 4 5 →