Kinetic characteristics of the reaction of resveratrol with peroxyl radicals and natural thiols in aqueous medium

被引：9
|
作者：
Zinatullina, K. M. [1 ,2 ,3 ]
Khrameeva, N. P. [2 ]
Kasaikina, O. T. [4 ]
Shapiro, B. I. [2 ]
Kuzmin, V. A. [2 ,4 ]
机构：
[1] Russian Acad Sci, NN Semenov Inst Chem Phys, 4 Ul Kosygina, Moscow 119991, Russia
[2] Russian Acad Sci, NM Emanuel Inst Biochem Phys, 4 Ul Kosygina, Moscow 119991, Russia
[3] PG Demidov Yaroslavl State Univ, 14 Ul Sovetskaya, Yaroslavl 150000, Russia
[4] Moscow MV Lomonosov State Univ, Dept Chem, Build 3,1 Leninskie Gory, Moscow 119991, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2017年 / 66卷 / 11期
基金：
俄罗斯科学基金会;
关键词：
resveratrol; thiol-ene reaction; glutathione; cysteine; antioxidants; kinetics; CORONARY-HEART-DISEASE; ANTIOXIDANT ACTIVITY; TRANS-RESVERATROL; RED WINE; PLATELET-AGGREGATION; INDUCED PEROXIDATION; LIPID-PEROXIDATION; BIOLOGICAL-SYSTEMS; CLICK CHEMISTRY; VITIS-VINIFERA;
D O I：
10.1007/s11172-017-1995-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The method of competing reactions was used to determine the rate constants of the reaction of resveratrol (RVT) with peroxyl radicals formed on decomposition of the azoinitiator DDD De in aqueous solutions at 37 A degrees D. The polymethine dye A (3,3'-di-gamma-sulfopropyl-9-metylthiacarbocyanine-betaine pyridinium salt) was used as a competing acceptor of radicals. It was found that resveratrol can be involved in the reaction with natural thiols, glutathione (GSH) and cysteine (CSH), in aqueous solutions at 37 A degrees. The reaction of RVT with thiols (thiol-D mu ne reaction) follows a chain mechanism and accelerates in the presence of De(2)D(2). The results obtained can be useful for understanding the physiological role of thiols in oxidation processes.
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页码：2145 / 2151
页数：7
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