Morphing Hydrogel Patterns by Thermo-Reversible Fluorescence Switching

被引:27
|
作者
Bat, Erhan [1 ,2 ]
Lin, En-Wei [1 ,2 ]
Saxer, Sina [1 ,2 ]
Maynard, Heather D. [1 ,2 ]
机构
[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA
基金
瑞士国家科学基金会;
关键词
electron beam lithography; fluorescence; oligo-(ethylene glycol); stimuli-responsive surfaces; thermo-responsive polymers; ANIONIC POLYMERIZATIONS; DRUG-DELIVERY; TRANSITION; SURFACES;
D O I
10.1002/marc.201400160
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Stimuli responsive surfaces that show reversible fluorescence switching behavior in response to temperature changes were fabricated. Oligo(ethylene glycol) methacrylate thermoresponsive polymers with amine end-groups were prepared by atom transfer radical polymerization (ATRP). The polymers were patterned on silicon surfaces by electron beam (e-beam) lithography, followed by conjugation of self-quenching fluorophores. Fluorophore conjugated hydrogel thin films were bright when the gels were swollen; upon temperature-induced collapse of the gels, self-quenching of the fluorophores led to significant attenuation of fluorescence. Importantly, the fluorescence was regained when the temperature was cooled. The fluorescence switching behavior of the hydrogels for up to ten cycles was investigated and the swelling-collapse was verified by atomic force microscopy. Morphing surfaces that change shape several times upon increase in temperature were obtained by patterning multiple stimuli responsive polymers.
引用
收藏
页码:1260 / 1265
页数:6
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