Increased expression and redistribution of the antiapoptotic molecule Bcl-xL in Parkinson's disease

被引：40
|
作者：
Hartmann, A [1 ]
Mouatt-Prigent, A
Vila, M
Abbas, N
Perier, C
Faucheux, BA
Vyas, S
Hirsch, EC
机构：
[1] Hop La Pitie Salpetriere, INSERM, U289, F-75013 Paris, France
[2] Ecole Normale Super, INSERM, U497, F-75231 Paris, France
来源：
NEUROBIOLOGY OF DISEASE | 2002年 / 10卷 / 01期
关键词：
Parkinson's disease; apoptosis; mitochondria; Bcl-x(L);
D O I：
10.1006/nbdi.2002.0494
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In the present study, we tried to clarify the potentially protective role of Bcl-X-L, an anti-apoptotic member of the Bcl-2 family of proteins, in Parkinson's disease (1313). Using In situ hybridization on human postmortem mesencephalon sections, we show that in PD patients Bcl-X-L mRNA expression per dopaminergic neuron was almost double that of controls. We also show that, ultrastructurally, this effect may be mediated by a redistribution of BCl-X-L from the cytosol to the outer mitochondrial membrane. (C) 2002 Elsevier Science (USA).
引用
收藏
页码：28 / 32
页数：5
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