Type 1 Diabetes Mellitus and Isolated Adrenocorticotropin Deficiency Manifested by Parkinsonism: A Case Report and Literature Review

被引：6

作者：

Ohara, Nobumasa ^{[1
,2
]}

Kojima, Naoyuki ^{[3
]}

Sato, Takashi ^{[4
]}

Ikarashi, Tomoo ^{[1
]}

Sone, Hirohito ^{[2
]}

Oki, Yutaka ^{[5
]}

Kamoi, Kyuzi

Hara, Masao ^{[1
]}

Sasaki, Hideo ^{[1
]}

机构：

[1] Niigata Med Ctr, Dept Endocrinol & Metab, Niigata, Japan

[2] Niigata Univ, Fac Med, Dept Hematol Endocrinol & Metab, Niigata 95021, Japan

[3] Niigata Med Ctr, Dept Neurol, Niigata, Japan

[4] Niigata Med Ctr, Dept Orthoped Surg, Niigata, Japan

[5] Hamamatsu Univ Sch Med, Dept Internal Med, Div 1, Hamamatsu, Shizuoka, Japan

来源：

INTERNAL MEDICINE | 2015年 / 54卷 / 20期

关键词：

isolated adrenocorticotropin deficiency; type 1 diabetes mellitus; Hashimoto thyroiditis; polyglandular autoimmune syndrome; parkinsonism; orthopedic surgery; ISOLATED ACTH DEFICIENCY; STIFF-PERSON SYNDROME; EXTRAPONTINE MYELINOLYSIS; HORMONE DEFICIENCY; DIAGNOSTIC-CRITERIA; GROWTH-HORMONE; HYPOGLYCEMIA; COMMITTEE; FULMINANT; SOCIETY;

D O I：

10.2169/internalmedicine.54.5022

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 67-year-old woman developed isolated adrenocorticotropin deficiency (IAD), which manifested as lethargy, a 20-kg body weight loss, hypoglycemia, and parkinsonism, and began corticosteroid replacement. Her symptoms resolved rapidly, and her weight returned to normal within six months. However, she then developed slowly progressive type 1 diabetes mellitus (T1D) with co-existing Hashimoto thyroiditis, and commenced insulin therapy. To our knowledge, this is the first reported case of parkinsonism associated with IAD. In addition, because diabetes mellitus, including T1D, could be latent in patients with untreated IAD, careful assessment of glucose metabolism is needed after commencing corticosteroid replacement until weight regain is achieved.

引用

页码：2629 / 2635

页数：7

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