One-pot two-step sequential transformation: Highly efficient construction of o-2,3,5,6-tetrafluorobenzonitrile substituted oximes ethers

被引：7

作者：

Liu, Cuibo ^{[1
]}

Yin, Xuguang ^{[1
]}

Chang, Jing ^{[1
]}

Tang, Xiangyang ^{[1
]}

Zhang, Bin ^{[1
,2
]}

机构：

[1] Tianjin Univ, Sch Sci, Dept Chem, Tianjin 300072, Peoples R China

[2] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2014年 / 165卷

关键词：

Polyfluoroarenes; C-F bond cleavage; One-pot two-step; o-Arylated oximes; PENTAFLUOROBENZONITRILE; POLYFLUOROARENES; FLUORINE; REAGENTS; ACID;

D O I：

10.1016/j.jfluchem.2014.06.011

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A practical variety of o-2,3,5,6-tetrafluorobenzonitrile substituted oximes ethers bearing broad functional groups were synthesized in moderate to good yields. The key highlight of this disclosure involving a one-pot two-step tandem procedure in aqueous media: the in situ formation of aryl aldehydes or ketones oximes followed by the SNAr reaction with pentafluorobenzonitrile via the high selective C-F bond cleavage. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：101 / 108

页数：8

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