A green analytical method for the analysis of polycyclic aromatic hydrocarbons in oral fluids from crack smokers

被引：0
|
作者：
Rossiter, Pavla Lobo [1 ]
de Alencar Danda, Lucas Jose [1 ]
Pimentel, Maria Fernanda [2 ]
Almeida Silva de Santana, Danielle Cristine [1 ]
Malagueno de Santana, Fernando Jose [1 ]
机构：
[1] Univ Fed Pernambuco, Dept Pharmaceut Sci, Av Prof Moraes Rego 1235, BR-50670901 Recife, PE, Brazil
[2] Univ Fed Pernambuco, Dept Chem Engn, Av Prof Moraes Rego 1235, BR-50670901 Recife, PE, Brazil
来源：
BIOANALYSIS | 2020年 / 12卷 / 24期
关键词：
crack cocaine; liquid chromatography; oral fluid; polycyclic aromatic hydrocarbon; solid-phase microextraction; SOLID-PHASE MICROEXTRACTION; CHROMATOGRAPHY-MASS SPECTROMETRY; ROADSIDE SOIL; DISTRIBUTION BEHAVIOR; TRAFFIC INTERCEPTS; HUMAN SALIVA; HUMAN URINE; COCAINE USE; WATER; EXPOSURE;
D O I：
10.4155/bio-2020-0251
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Aim: Develop and validate a method of solid-phase microextraction (SPME) and liquid chromatography to investigate three major polycyclic aromatic hydrocarbons (PAHs) in oral fluid. Results/Methodology: The extraction phase was exposed to 1.5 ml of diluted oral fluid under stirring at 1000 rpm for 60 min, at 70 degrees C. Then, it was immersed in 200 mu l of acetonitrile for 10 min at 25 degrees C for desorption of the analytes. Linearity, absolute recovery, and inter- and intra-assay relative standard deviations and relative errors were 50-300 ng.ml(-1), >= 24% and <= 15% for all analytes, respectively. A full factorial design was used to SPME optimization. Discussion/Conclusion: The method is suitable for the exploratory analysis of some PAHs in the oral fluid of crack smokers.
引用
收藏
页码：1711 / 1724
页数：14
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