Synthesis and morphine enhancement activity of N-[5-(2-phenoxyphenyl)-1 3,4-oxadiazole-2-yl]-N′-phenylurea derivatives

被引：3

作者：

Rad, AA

Sheikhha, M

Hosseini, R

Tabatabai, SA

Shafiee, A

机构：

[1] Univ Tehran Med Sci, Dept Med Chem, Fac Pharm, Tehran, Iran

[2] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Fac Pharm, Tehran, Iran

[3] Univ Tehran Med Sci, Dept Pharmacol & Toxicol, Fac Pharm, Tehran, Iran

[4] Shaheed Beheshti Univ Med Sci, Fac Pharm, Dept Med Chem, Tehran, Iran

来源：

ARCHIV DER PHARMAZIE | 2004年 / 337卷 / 04期

关键词：

1,3,4-oxadiazole; L-365,260, CCK-B antagonist; morphine enhancement; analgesia;

D O I：

10.1002/ardp.200300822

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of N-[5-(2-phenoxyphenyl)-1,3,4-oxadiazole-2-yl]-N'-phenylurea derivatives is reported. The structures of these compounds are supported by their IR, (1)H-NMR and mass spectra. Conformational analysis and superimposition of energy minima conformers of these compounds on L-365,260, a known 3-ureido-1 4-benzodiazepine CCK-B antagonist, showed that the aromatic rings fell in the same contour. Morphine analgesia enhancement evaluation of the synthesized compounds in comparison with a control group showed that compounds 8a, 8c, 8h-8j, 8l, 8o have significant effects.

引用

页码：193 / 200

页数：8

共 50 条

[41] Synthesis and antimicrobial activity of 5-(1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazole derivatives
Konstantin Yu. Krolenko
Sergiy V. Vlasov
Irina A. Zhuravel
Chemistry of Heterocyclic Compounds, 2016, 52 : 823 - 830
[42] Synthesis and antimicrobial activity of 5-(1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazole derivatives
Krolenko, Konstantin Yu.
Vlasov, Sergiy V.
Zhuravel, Irina A.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2016, 52 (10) : 823 - 830
[43] SYNTHESIS AND ANTIBACTERIAL EVALUATION OF N-(AZETIDIN-2-ON-1-YL)/N-(THIAZOLIDIN-3-ON-1-YL) CARBAMOYLCOUMARINS
Jeyachandran, M.
Ramesh, P.
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2009, 19 (02) : 195 - 196
[44] Design, Synthesis and Fungicidal Activity of N-(thiophen-2-yl) Nicotinamide Derivatives
Wu, Hongfei
Lu, Xingxing
Xu, Jingbo
Zhang, Xiaoming
Li, Zhinian
Yang, Xinling
Ling, Yun
MOLECULES, 2022, 27 (24):
[45] Syntheses of (3-benzyl-4-aroyl-1,2,4-triazole-5-yl)[5-(3,4,5-trimethoxylphenyl)-1,3,4-oxadiazole-2-yl] sulfides
Feng, XM
Chen, R
Tang, LF
Jiang, YZ
CHINESE CHEMICAL LETTERS, 1997, 8 (03) : 195 - 198
[46] Synthesis and antibacterial activity of N-[5-chlorobenzylthio-1,3,4-thiadiazol-2-yl] piperazinyl quinolone derivatives
Alireza Foroumadi
Loghman Firoozpour
Saeed Emami
Shahla Mansouri
Abdolrasoul H. Ebrahimabadi
Ali Asadipour
Mohsen Amini
Nosratollah Saeid-Adeli
Abbas Shafiee
Archives of Pharmacal Research, 2007, 30
[47] Synthesis of N-[5-(guanidinopentyl)-N-[3-[(3-methyl-1-oxo-2 butenyl) amino] propyldodecanamide
Abdalla, Walwil M.
RESEARCH JOURNAL OF CHEMISTRY AND ENVIRONMENT, 2008, 12 (04): : 70 - 75
[48] Synthesis and acaricidal activity of N-(1,3,4-thiadiazol-2-yl)carboxamides
Shiga, Y
Okada, I
Fukuchi, T
JOURNAL OF PESTICIDE SCIENCE, 2003, 28 (01): : 58 - 60
[49] Synthesis and acaricidal activity of N-(1,3,4-thiadiazol-2-yl)cyclopropanecarboxamides
Shiga, Y
Okada, I
Fukuchi, T
JOURNAL OF PESTICIDE SCIENCE, 2003, 28 (01): : 61 - 63
[50] Synthesis and biological activity of novel N-(5-((1H-1,2,4-triazol-1-yl) methyl)-4-tert-butylthiazol-2-yl)-4-carboxamide derivatives
Qin, Xue
Yu, Haibo
Liu, Jianbing
Dai, Hong
Bing, Guifang
Qin, Zhenfang
Zhang, Xin
Wang, Tingting
Fang, Jianxin
ARKIVOC, 2009, : 201 - 210

← 1 2 3 4 5 →