Reactive radical scavenging and xanthine oxidase inhibition of proanthocyanidins from Carallia brachiata

被引：23
|
作者：
Phuwapraisirisan, Preecha
Sowanthip, Preecha
Miles, D. Howard
Tip-pyang, Santi [1 ]
机构：
[1] Chulalongkorn Univ, Fac Sci, Dept Chem, Nat Prod Res Unit, Bangkok 10330, Thailand
[2] Univ Cent Florida, Dept Chem, Orlando, FL 32816 USA
来源：
PHYTOTHERAPY RESEARCH | 2006年 / 20卷 / 06期
关键词：
Carallia brachiata; carallidin; antioxidant; proanthocyanidin; xanthine oxidase; radical scavenging;
D O I：
10.1002/ptr.1877
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Antioxidant-guided separation of Carallia brachiata bark led to a new A-type trimeric proanthocyanidin named carallidin (1), along with mahuarmin A (2) and p-hydroxy benzoic acid (3). The structure of 1 was fully characterized by interpretation of spectroscopic data and chemical means. Compounds 1 and 2 exhibited radical scavenging against DPPH (IC50 102 and 182 mu m) and superoxide radical (IC50 1.47 and 9.74 mu m). In addition, 1 and 2 also inhibited xanthine oxidase with IC, values of 12.9 and 16.0 mu m. Copyright (c) 2006 John Wiley & Sons, Ltd.
引用
收藏
页码：458 / 461
页数：4
相关论文
共 50 条
  • [31] Phytochemicals screening, DPPH free radical scavenging and xanthine oxidase inhibitiory activities of Cassia fistula seeds extract
    Jothy, Subramanion L.
    Zuraini, Zakaria
    Sasidharan, Sreenivasan
    JOURNAL OF MEDICINAL PLANTS RESEARCH, 2011, 5 (10): : 1941 - 1947
  • [32] Post-irradiation free radical generation: Evidence from the conversion of xanthine dehydrogenase into xanthine oxidase
    Kale, R.K.
    Indian Journal of Experimental Biology, 2003, 41 (02) : 105 - 111
  • [33] THE PROTECTION FROM POSTISCHEMIC INJURY BY XANTHINE-OXIDASE INHIBITION - BLOCKADE OF FREE-RADICAL GENERATION OR PURINE SALVAGE
    MORRIS, JB
    HAGLUND, U
    BULKLEY, GB
    GASTROENTEROLOGY, 1987, 92 (05) : 1542 - 1542
  • [34] INHIBITION BY NILVADIPINE OF ISCHEMIC AND CARRAGEENAN PAW EDEMA AS WELL AS OF SUPEROXIDE RADICAL PRODUCTION FROM NEUTROPHILS AND XANTHINE-OXIDASE
    OYANAGUI, Y
    SATO, S
    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1991, 41-1 (05): : 469 - 474
  • [35] INHIBITION OF XANTHINE-OXIDASE BY URIC-ACID AND ITS INFLUENCE ON SUPEROXIDE RADICAL PRODUCTION
    RADI, R
    TAN, S
    PRODANOV, E
    EVANS, RA
    PARKS, DA
    BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1122 (02) : 178 - 182
  • [36] Invitro antiperoxidative, free radical scavenging and xanthine oxidase inhibitory potentials of ethyl acetate fraction of Saraca ashoka flowers
    Prathapan, A.
    Cherian, O. Lijo
    Nampoothiri, Suresh V.
    Mini, S.
    Raghu, K. G.
    NATURAL PRODUCT RESEARCH, 2011, 25 (03) : 298 - 309
  • [37] Inhibition of xanthine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis
    L. D. Kong
    Y. Zhang
    X. Pan
    R. X. Tan
    C. H. K. Cheng*
    Cellular and Molecular Life Sciences CMLS, 2000, 57 : 500 - 505
  • [38] Inhibition of xanthine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis
    Kong, LD
    Zhang, Y
    Pan, X
    Tan, RX
    Cheng, CHK
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2000, 57 (03) : 500 - 505
  • [39] Structure-activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities
    Lin, Hsiu-Chen
    Tsai, Shin-Hui
    Chen, Chien-Shu
    Chang, Yuan-Ching
    Lee, Chi-Ming
    Lai, Zhi-Yany
    Lin, Chun-Mao
    BIOCHEMICAL PHARMACOLOGY, 2008, 75 (06) : 1416 - 1425
  • [40] Xanthine Oxidase Inhibition of Bioactive Constituents Isolated from Potentilla evestita
    Rauf, Abdur
    Khan, Rehan
    Khan, Haroon
    Khan, Inamullah
    Akram, Muhammad
    JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, 2016, 38 (01): : 139 - 142
12345