Reactive radical scavenging and xanthine oxidase inhibition of proanthocyanidins from Carallia brachiata

被引：23
|
作者：
Phuwapraisirisan, Preecha
Sowanthip, Preecha
Miles, D. Howard
Tip-pyang, Santi [1 ]
机构：
[1] Chulalongkorn Univ, Fac Sci, Dept Chem, Nat Prod Res Unit, Bangkok 10330, Thailand
[2] Univ Cent Florida, Dept Chem, Orlando, FL 32816 USA
来源：
PHYTOTHERAPY RESEARCH | 2006年 / 20卷 / 06期
关键词：
Carallia brachiata; carallidin; antioxidant; proanthocyanidin; xanthine oxidase; radical scavenging;
D O I：
10.1002/ptr.1877
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Antioxidant-guided separation of Carallia brachiata bark led to a new A-type trimeric proanthocyanidin named carallidin (1), along with mahuarmin A (2) and p-hydroxy benzoic acid (3). The structure of 1 was fully characterized by interpretation of spectroscopic data and chemical means. Compounds 1 and 2 exhibited radical scavenging against DPPH (IC50 102 and 182 mu m) and superoxide radical (IC50 1.47 and 9.74 mu m). In addition, 1 and 2 also inhibited xanthine oxidase with IC, values of 12.9 and 16.0 mu m. Copyright (c) 2006 John Wiley & Sons, Ltd.
引用
收藏
页码：458 / 461
页数：4
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