Membrane expression of trail receptors DcR1 and DcR2 in the normal endometrium, endometrial atypical hyperplasia and endometrioid endometrial cancer

被引：3

作者：

Gottwald, L. ^{[1
,5
]}

Pasz-Walczak, G. ^{[2
]}

Piekarski, J. ^{[3
]}

Szwalski, J. ^{[7
]}

Kubiak, R. ^{[2
]}

Spych, M. ^{[1
,6
]}

Suzin, J. ^{[4
]}

Tylinski, W. ^{[4
]}

Sek, P. ^{[3
]}

Jeziorski, A. ^{[3
]}

机构：

[1] Med Univ Lodz, Dept Radiotherapy, Lodz, Poland

[2] Med Univ Lodz, Dept Pathol, Lodz, Poland

[3] Med Univ Lodz, Dept Surg Oncol, Lodz, Poland

[4] Med Univ Lodz, Dept Gynecol & Gynecol Oncol, Lodz, Poland

[5] Copernicus Mem Hosp, Reg Canc Ctr, Dept Teleradiotherapy, PL-93509 Lodz, Poland

[6] Copernicus Mem Hosp, Reg Canc Ctr, Dept Radiotherapy & Gen Oncol, PL-93509 Lodz, Poland

[7] Olympus Consilio Co Ltd, Histopathol Unit, Lodz, Poland

来源：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2014年 / 34卷 / 04期

关键词：

DcR1; DcR2; endometrial atypical hyperplasia; endometrial cancer; immunohistochemistry; normal endometrium; TRAIL; APOPTOSIS-INDUCING LIGAND; DECOY RECEPTOR; MEMBER; FAMILY; CELLS;

D O I：

10.3109/01443615.2014.889667

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We aimed to evaluate the membrane expression of DcR1 and DcR2 in the normal endometrium (NE), endometrial atypical hyperplasia (EAH) and endometrioid endometrial cancer (EEC). The study comprised 101 patients: 20 NE, 14 EAH and 67 EEC. Membrane expression of DcR1 and DcR2 was examined and presented as total score (TS). The membrane expression of both DcR1 and DcR2 was more common in EEC than in NE (p < 0.001; p < 0.001). A strong correlation was found between type of endometrial tissue (NE/EAH/EEC) and the TS of DcR1 (p = 0.001) and DcR2 (p = 0.001). In EEC, the TS of DcR1 and DcR2 was not related to grading and survival. The TS of DcR1 negatively correlated with staging (p = 0.018), but DcR2 did not. The membrane expression of decoy receptors for TRAIL DcR1 and DcR2 is greater in NE than EEC. In EEC patients, membrane expression of DcR1 and DcR2 are not independent predictors of survival.

引用

下载

页码：346 / 349

页数：4

共 50 条

[41] Expression and localization of progesterone receptor membrane component 1 and 2 in normal and malignant endometrial cells
Kavandi, Leyla
Ivanova, Vessela S.
Huyen Nguyen
Syed, Vigar
CANCER RESEARCH, 2011, 71
[42] Loss of expression of MLH1, MSH2, MSH6, and PTEN related to endometrial cancer in 68 patients with endometrial hyperplasia
Orbo, A
Nilsen, MN
Arnes, MS
Pettersen, I
Larsen, K
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2003, 22 (02) : 141 - 148
[43] Tissue microarray immunohistochemical expression analysis of mismatch repair (hMLH1 and hMSH2 genes) in endometrial carcinoma and atypical endometrial hyperplasia:: Relationship with microsatellite instability
Hardisson, D
Moreno-Bueno, G
Sánchez, L
Sarrió, D
Suárez, A
Calero, F
Palacios, J
MODERN PATHOLOGY, 2003, 16 (11) : 1148 - 1158
[44] FIGO stage IIIC endometrial cancer identification among patients with complex atypical hyperplasia, grade 1 and 2 endometrioid endometrial cancer: laparoscopic indocyanine green sentinel lymph node mapping versus frozen section of the uterus, why get around the problem?
Papadia, Andrea
Gasparri, Maria Luisa
Siegenthaler, Franziska
Imboden, Sara
Mohr, Stefan
Mueller, Michael D.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2017, 143 (03) : 491 - 497
[45] FIGO stage IIIC endometrial cancer identification among patients with complex atypical hyperplasia, grade 1 and 2 endometrioid endometrial cancer: laparoscopic indocyanine green sentinel lymph node mapping versus frozen section of the uterus, why get around the problem?
Andrea Papadia
Maria Luisa Gasparri
Franziska Siegenthaler
Sara Imboden
Stefan Mohr
Michael D. Mueller
Journal of Cancer Research and Clinical Oncology, 2017, 143 : 491 - 497
[46] Cancer history and loss of MSH2 and MLH1 protein expression in patients with endometrial hyperplasia
Maruyama, A
Saito, T
Hachitanda, Y
Tsukamoto, N
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2003, 13 (03) : 352 - 360
[47] Distribution of basement membrane anchoring molecules in normal and transformed endometrium: Altered expression of laminin γ2 chain and collagen type XVII in endometrial adenocarcinomas
Marko Määttä
Sirpa Salo
Kaisa Tasanen
Ylermi Soini
Annikki Liakka
Leena Bruckner-Tuderman
Helena Autio-Harmainen
Journal of Molecular Histology, 2004, 35 : 715 - 722
[48] Distribution of basement membrane anchoring molecules in normal and transformed endometrium:: Altered expression of laminin γ2 chain and collagen type XVII in endometrial adenocarcinomas
Määttä, M
Salo, S
Tasanen, K
Soini, Y
Liakka, A
Bruckner-Tuderman, L
Autio-Harmainen, H
JOURNAL OF MOLECULAR HISTOLOGY, 2004, 35 (8-9) : 715 - 722
[49] Expression Patterns of Cytokeratins (CK7, CK20, CK19, CK AE1/AE3) in Atypical Endometrial Hyperplasia Coexisting with Endometrial Cancer
Vasilevska, Danuta
Rudaitis, Vilius
Lewkowicz, Dorota
Sirviene, Dominika
Mickys, Ugnius
Semczuk, Marek
Obrzut, Bogdan
Semczuk, Andrzej
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (16)
[50] The expression ratios of estrogen receptor α (ERα) to estrogen receptor β1 (ERβ1) and ERα to ERβ2 identify poor clinical outcome in endometrioid endometrial cancer
Zannoni, Gian Franco
Monterossi, Giorgio
De Stefano, Ilaria
Gargini, Antonio
Salerno, Maria Giovanna
Farulla, Ilaria
Travaglia, Daniele
Vellone, Valerio Gaetano
Scambia, Giovanni
Gallo, Daniela
HUMAN PATHOLOGY, 2013, 44 (06) : 1047 - 1054

← 1 2 3 4 5 →