Membrane expression of trail receptors DcR1 and DcR2 in the normal endometrium, endometrial atypical hyperplasia and endometrioid endometrial cancer

被引：3

作者：

Gottwald, L. ^{[1
,5
]}

Pasz-Walczak, G. ^{[2
]}

Piekarski, J. ^{[3
]}

Szwalski, J. ^{[7
]}

Kubiak, R. ^{[2
]}

Spych, M. ^{[1
,6
]}

Suzin, J. ^{[4
]}

Tylinski, W. ^{[4
]}

Sek, P. ^{[3
]}

Jeziorski, A. ^{[3
]}

机构：

[1] Med Univ Lodz, Dept Radiotherapy, Lodz, Poland

[2] Med Univ Lodz, Dept Pathol, Lodz, Poland

[3] Med Univ Lodz, Dept Surg Oncol, Lodz, Poland

[4] Med Univ Lodz, Dept Gynecol & Gynecol Oncol, Lodz, Poland

[5] Copernicus Mem Hosp, Reg Canc Ctr, Dept Teleradiotherapy, PL-93509 Lodz, Poland

[6] Copernicus Mem Hosp, Reg Canc Ctr, Dept Radiotherapy & Gen Oncol, PL-93509 Lodz, Poland

[7] Olympus Consilio Co Ltd, Histopathol Unit, Lodz, Poland

来源：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2014年 / 34卷 / 04期

关键词：

DcR1; DcR2; endometrial atypical hyperplasia; endometrial cancer; immunohistochemistry; normal endometrium; TRAIL; APOPTOSIS-INDUCING LIGAND; DECOY RECEPTOR; MEMBER; FAMILY; CELLS;

D O I：

10.3109/01443615.2014.889667

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We aimed to evaluate the membrane expression of DcR1 and DcR2 in the normal endometrium (NE), endometrial atypical hyperplasia (EAH) and endometrioid endometrial cancer (EEC). The study comprised 101 patients: 20 NE, 14 EAH and 67 EEC. Membrane expression of DcR1 and DcR2 was examined and presented as total score (TS). The membrane expression of both DcR1 and DcR2 was more common in EEC than in NE (p < 0.001; p < 0.001). A strong correlation was found between type of endometrial tissue (NE/EAH/EEC) and the TS of DcR1 (p = 0.001) and DcR2 (p = 0.001). In EEC, the TS of DcR1 and DcR2 was not related to grading and survival. The TS of DcR1 negatively correlated with staging (p = 0.018), but DcR2 did not. The membrane expression of decoy receptors for TRAIL DcR1 and DcR2 is greater in NE than EEC. In EEC patients, membrane expression of DcR1 and DcR2 are not independent predictors of survival.

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页码：346 / 349

页数：4

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