Regioselective hydrolysis of cocaine and a convenient acylation procedure by benzoylecgonine

被引：3
|
作者：
Martinet, F
Huy, CP
Tomas, A
Scherrmann, JM
Galons, H
机构：
[1] FAC PHARM, CHIM ORGAN LAB, F-75270 PARIS, FRANCE
[2] HOP FERNAND WIDAL, F-75010 PARIS, FRANCE
来源：
SYNTHETIC COMMUNICATIONS | 1997年 / 27卷 / 19期
关键词：
HIGH-AFFINITY; ANALOGS; TRANSPORTER; ESTER;
D O I：
10.1080/00397919708005651
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Regioselective hydrolysis of cocaine led, according to the reaction conditions, either to benzoylecgonine or to ecgonine methyl ester. Acylation with benzoylecgonine was readily achieved when benzotriazolyloxytrisdimethylaminophosphonium (BOP) was used as a coupling agent.
引用
收藏
页码：3485 / 3490
页数：6
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