Excitation/Inhibition Imbalance in Animal Models of Autism Spectrum Disorders

被引：320
|
作者：
Lee, Eunee [1 ]
Lee, Jiseok [2 ]
Kim, Eunjoon [1 ,2 ]
机构：
[1] Korea Adv Inst Sci & Technol, Inst Basic Sci, Ctr Synapt Brain Dysfunct, Daejeon 34141, South Korea
[2] Korea Adv Inst Sci & Technol, Dept Biol Sci, Daejeon, South Korea
来源：
BIOLOGICAL PSYCHIATRY | 2017年 / 81卷 / 10期
关键词：
Autism spectrum disorders; Circuit; Excitation/inhibition balance; Mouse models; Psychiatric disorders; Synapse; LONG-TERM POTENTIATION; FRAGILE-X-SYNDROME; CYCLOSERINE IMPROVES SOCIABILITY; MEDIAL PREFRONTAL CORTEX; BTBR MOUSE MODEL; MICE LACKING; SOCIAL-INTERACTION; GABA(A) RECEPTOR; SYNAPTIC-TRANSMISSION; MUTANT MICE;
D O I：
10.1016/j.biopsych.2016.05.011
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Imbalances between excitation and inhibition in synaptic transmission and neural circuits have been implicated in autism spectrum disorders. Excitation and inhibition imbalances are frequently observed in animal models of autism spectrum disorders, and their correction normalizes key autistic-like phenotypes in these animals. These results suggest that excitation and inhibition imbalances may contribute to the development and maintenance of autism spectrum disorders and represent an important therapeutic target.
引用
收藏
页码：838 / 847
页数：10
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