Solution structure and dynamics of the DNA-binding domain of the adipocyte-transcription factor FREAC-11

被引:51
|
作者
van Dongen, MJP
Cederberg, A
Carlsson, P
Enerbäck, S
Wikström, M
机构
[1] Pharmacia & Upjohn, Dept Struct Chem, S-11287 Stockholm, Sweden
[2] Gothenburg Univ, Dept Mol Biol, Lundberg Lab, S-41390 Gothenburg, Sweden
关键词
FREAC; forkhead; winged helix; NMR structure; dynamics;
D O I
10.1006/jmbi.1999.3476
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Transcription factors of the forkhead type share a highly conserved DNA-binding domain of about 100 amino acid residues. FREAC-11, expressed in adipocytes, belongs to this class. Here, we report on NMR studies that established the three-dimensional structure of the FREAC-11, DNA-binding domain. Although apparent similarities to the structures of other members within the forkhead family are observed, the structure also reveals some remarkable differences. Along with the complementary dynamics, the data provide insight into the fundamentals of sequence specificity within a highly conserved motif. (C) 2000 Academic Press.
引用
收藏
页码:351 / 359
页数:9
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