Accelerated Dissolution Method to Facilitate In Vitro Evaluation of Risperidone-Containing Microspheres

被引：3
|
作者：
Ma, Cheng [1 ]
Fu, Han [2 ]
Huang, Zhengwei [1 ]
Ma, Xiangyu [3 ]
Liu, Yang [4 ]
Wang, Wenhua [1 ]
Wu, Mingjun [1 ]
Zhang, Xuejuan [1 ,5 ]
Huang, Ying [1 ]
Wu, Chuanbin [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China
[2] Shenzhen Ctr Chron Dis Control, Shenzhen, Peoples R China
[3] Univ Texas Austin, Coll Pharm Mol Pharmaceut & Drug Delivery, Austin, TX 78712 USA
[4] Chongqing Med & Pharmaceut Coll, Chongqing, Peoples R China
[5] Guangdong Univ Technol, Inst Biomed & Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China
来源：
DISSOLUTION TECHNOLOGIES | 2019年 / 26卷 / 02期
关键词：
Microspheres; in vitro evaluation; accelerated dissolution method; model fitting; PLGA MICROSPHERES; RELEASE; PARAMETERS; FABRICATION; DELIVERY; PEPTIDE; TABLETS;
D O I：
10.14227/DT260219P48
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Microspheres have gained much interest because of their simple and controllable manufacturing process, sustained-release profile, and drug stabilization. However, the in vitro dissolution test of sustained-release microspheres is time consuming and impedes the development and quality control of microsphere products. In this study, an accelerated dissolution method was established to develop and evaluate microspheres in a timely and cost-effective manner. The effects of dissolution media temperature, pH, and ethanol content on the dissolution behavior were investigated to optimize the accelerated dissolution method. Media containing 25% ethanol with pH 7.4 and 37 degrees C was suitable for the microspheres. The correlation between the real-time and accelerated dissolution tests was established successfully with an R-2 = 0.9978, indicating potential to apply the accelerated dissolution method to the development and evaluation of microspheres.
引用
收藏
页码：48 / 55
页数：8
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