Accelerated Dissolution Method to Facilitate In Vitro Evaluation of Risperidone-Containing Microspheres

被引：3
|
作者：
Ma, Cheng [1 ]
Fu, Han [2 ]
Huang, Zhengwei [1 ]
Ma, Xiangyu [3 ]
Liu, Yang [4 ]
Wang, Wenhua [1 ]
Wu, Mingjun [1 ]
Zhang, Xuejuan [1 ,5 ]
Huang, Ying [1 ]
Wu, Chuanbin [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China
[2] Shenzhen Ctr Chron Dis Control, Shenzhen, Peoples R China
[3] Univ Texas Austin, Coll Pharm Mol Pharmaceut & Drug Delivery, Austin, TX 78712 USA
[4] Chongqing Med & Pharmaceut Coll, Chongqing, Peoples R China
[5] Guangdong Univ Technol, Inst Biomed & Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China
来源：
DISSOLUTION TECHNOLOGIES | 2019年 / 26卷 / 02期
关键词：
Microspheres; in vitro evaluation; accelerated dissolution method; model fitting; PLGA MICROSPHERES; RELEASE; PARAMETERS; FABRICATION; DELIVERY; PEPTIDE; TABLETS;
D O I：
10.14227/DT260219P48
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Microspheres have gained much interest because of their simple and controllable manufacturing process, sustained-release profile, and drug stabilization. However, the in vitro dissolution test of sustained-release microspheres is time consuming and impedes the development and quality control of microsphere products. In this study, an accelerated dissolution method was established to develop and evaluate microspheres in a timely and cost-effective manner. The effects of dissolution media temperature, pH, and ethanol content on the dissolution behavior were investigated to optimize the accelerated dissolution method. Media containing 25% ethanol with pH 7.4 and 37 degrees C was suitable for the microspheres. The correlation between the real-time and accelerated dissolution tests was established successfully with an R-2 = 0.9978, indicating potential to apply the accelerated dissolution method to the development and evaluation of microspheres.
引用
收藏
页码：48 / 55
页数：8
相关论文
共 50 条
  • [1] Formation Mechanism and In Vitro Evaluation of Risperidone-Containing PLGA Microspheres Fabricated by Ultrafine Particle Processing System
    Huang, Zhengwei
    Chen, Xiaona
    Fu, Han
    Wen, Xinguo
    Ma, Cheng
    Zhang, Jiwen
    Wu, Chuanyu
    Huang, Ying
    Pan, Xin
    Wu, Chuanbin
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 106 (11) : 3363 - 3371
  • [2] An Accelerated Release Method of Risperidone Loaded PLGA Microspheres with Good IVIVC
    Hu, Xiaoqin
    Zhang, Jianwei
    Tang, Xuemei
    Li, Mingyuan
    Ma, Siyu
    Liu, Cheng
    Gao, Yue
    Zhang, Yue
    Liu, Yan
    Yu, Fanglin
    Yang, Yang
    Guo, Jia
    Li, Zhiping
    Mei, Xingguo
    CURRENT DRUG DELIVERY, 2018, 15 (01) : 87 - 96
  • [3] Pharmacokinetics and pharmacodynamics evaluation on risperidone-containing microsphere fabricated by ultra-fine particle processing system
    Ma, Cheng
    Fu, Han
    Huang, Zhengwei
    Chen, Xiaona
    Hu, Luni
    Ma, Xiangyu
    Huang, Ying
    Pan, Xin
    Wu, Chuanbin
    POWDER TECHNOLOGY, 2019, 358 : 13 - 19
  • [4] A reproducible accelerated in vitro release testing method for PLGA microspheres
    Shen, Jie
    Lee, Kyulim
    Choi, Stephanie
    Qu, Wen
    Wang, Yan
    Burgess, Diane J.
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 498 (1-2) : 274 - 282
  • [5] Formulation, in vitro and in vivo evaluation of transdermal patches containing risperidone
    Aggarwal, Geeta
    Dhawan, Sanju
    Kumar, S. L. Hari
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2013, 39 (01) : 39 - 50
  • [6] Preparation and in vitro evaluation of ethyl cellulose microspheres containing stavudine by the double emulsion method
    Sahoo, S. K.
    Mallick, A. A.
    Barik, B. B.
    Senapati, P. C.
    PHARMAZIE, 2007, 62 (02): : 117 - 121
  • [7] Preparation and in vitro evaluation of Eudragit microspheres containing theophylline
    Rathi, Jagdish Chandra
    Rathi, Vaishali
    Jain, Hemant Kumar
    Tamizharasi, S.
    ASIAN JOURNAL OF CHEMISTRY, 2008, 20 (08) : 6330 - 6334
  • [8] Preparation and in vitro evaluation of Eudragit microspheres containing cephalexin
    Tamizharasi, S.
    Rathi, J. C.
    Rathi, Vaishali
    ASIAN JOURNAL OF CHEMISTRY, 2008, 20 (02) : 845 - 848
  • [9] Preparation and in vitro evaluation of Eudragit microspheres containing acetazolamide
    Haznedar, S
    Dortunç, B
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2004, 269 (01) : 131 - 140
  • [10] Accelerated in vitro release testing method for naltrexone loaded PLGA microspheres
    Andhariya, Janki V.
    Choi, Stephanie
    Wang, Yan
    Zou, Yuan
    Burgess, Diane J.
    Shen, Jie
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 520 (1-2) : 79 - 85
12345