Recent advances in enantioselective copper-catalyzed 1,4-addition

被引：311

作者：

Jerphagnon, Thomas ^{[1
]}

Pizzuti, M. Gabriella ^{[1
]}

Minnaard, Adriaan J. ^{[1
]}

Feringa, Ben L. ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands

来源：

CHEMICAL SOCIETY REVIEWS | 2009年 / 38卷 / 04期

关键词：

ASYMMETRIC CONJUGATE ADDITION; QUATERNARY STEREOGENIC CENTERS; CHIRAL PHOSPHORUS LIGANDS; ALKOXY-NHC LIGANDS; DIALKYLZINC REAGENTS; GRIGNARD-REAGENTS; CYCLIC ENONES; ALPHA; BETA-UNSATURATED KETONES; ORGANOMETALLIC REAGENTS; ORGANOZINC REAGENTS;

D O I：

10.1039/b816853a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A comprehensive overview of recent literature from 2003 concerning advances in enantioselective copper catalysed 1,4-addition of organometallic reagents to alpha,beta-unsaturated compounds is given in this critical review. About 200 ligands and catalysts are presented, with a focus on stereoselectivities, catalyst loading, ligand structure and substrate scope. A major part is devoted to trapping and tandem reactions and a variety of recent synthetic applications are used to illustrate the practicality and current state of the art of 1,4-addition of organometallic reagents. Finally several mechanistic studies are discussed (162 references).

引用

页码：1039 / 1075

页数：37

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