Spatial Navigation: Implications for Animal Models, Drug Development and Human Studies

被引:15
|
作者
Stuchlik, A. [1 ]
Kubik, S. [1 ]
Vlcek, K. [1 ]
Vales, K. [1 ]
机构
[1] Acad Sci Czech Republ, Inst Physiol, Dept Neurophysiol Memory, CR-14220 Prague, Czech Republic
关键词
Memory; Learning; Navigation; Spatial representation; Moving environments; Rats; Animal models; Brain; Neurons; ALLOTHETIC PLACE AVOIDANCE; OBSESSIVE-COMPULSIVE DISORDER; VISUOSPATIAL WORKING-MEMORY; ADULT HIPPOCAMPAL NEUROGENESIS; CHECKING BEHAVIOR; LONG-EVANS; COGNITIVE COORDINATION; RECEPTOR ANTAGONIST; OPERANT-BEHAVIOR; HEAD-DIRECTION;
D O I
10.33549/physiolres.932660
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Spatial navigation and memory is considered to be a part of the declarative memory system and it is widely used as an animal model of human declarative memory. However, spatial tests typically involve only static settings, despite the dynamic nature of the real world. Animals, as well as people constantly need to interact with moving objects, other subjects or even with entire moving environments (flowing water, running stairway). Therefore, we design novel spatial tests in dynamic environments to study brain mechanisms of spatial processing in more natural settings with an interdisciplinary approach including neuropharmacology. We also translate data from neuropharmacological studies and animal models into development of novel therapeutic approaches to neuropsychiatric disorders and more sensitive screening tests for impairments of memory, thought, and behavior.
引用
收藏
页码:S237 / S249
页数:13
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