Characterization of a novel type of MLSB resistance plasmid from Staphylococcus saprophyticus carrying a constitutively expressed erm(C) gene

被引:14
|
作者
Hauschild, Tomasz
Luethje, Petra
Schwarz, Stefan
机构
[1] Bundesforschungsanstalt Landwirtschaft, Inst Tierzucht, D-31535 Neustadt Mariensee, Germany
[2] Univ Bialystok, Inst Biol, Dept Microbiol, PL-15950 Bialystok, Poland
关键词
macrolides; lincosamides; Streptogramins; resistance; translational attenuator; Staphylococcus;
D O I
10.1016/j.vetmic.2006.01.007
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
An erm(C)-carrying plasmid of unusual size and restriction map, designated pSES22, was identified in a Staphylococcus saprophyticus strain and sequenced completely. Constitutive expression of the erm(C) gene from pSES22 is based on a novel 22-bp tandem duplication in the erm(C) translational attenuator. Comparative analysis of the deduced Erm(C) amino acid sequence revealed that Erm(C) from pSES22 - together with an Erm(C) methylase from S. hyicus - represented a separate branch in the homology tree of Erm(C) methylases. Structural comparisons showed that plasmid pSES22 differed distinctly from all other completely sequenced erm(C)-carrying resistance plasmids. However, pSES22 was similar to several members of a diverse group of small plasmids, all of which carried closely related plasmid backbones consisting of the genes rep U and pre/mob, but differed in their resistance genes. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:258 / 263
页数:6
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