Multivalent Protein Binding and Precipitation by Self-Assembling Molecules on a DNA Pentaplex Scaffold

被引：48
|
作者：
Rosenzweig, Brooke A. [1 ]
Ross, Nathan T. [1 ]
Tagore, Debarati M. [1 ]
Jayawickramarajah, Janarthanan [1 ]
Saraogi, Ishu [1 ]
Hamilton, Andrew D. [1 ]
机构：
[1] Yale Univ, Dept Chem, New Haven, CT 06511 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 14期
关键词：
C-REACTIVE PROTEIN; LIGAND-BINDING; QUADRUPLEX; INHIBITORS; FRAGMENTS; TOXINS;
D O I：
10.1021/ja809219p
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A supramolecular assembly containing an isoguanosine pentaplex with both a "protein-binding" face and a "reporter" face has been generated. When phosphocholine is appended to the protein-binding face this supramolecular assembly binds multivalently to the pentameric human C-reactive protein, a biomolecule implicated in inflammation and heart disease.
引用
收藏
页码：5020 / +
页数：3
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