Structure, Function, and Drug Interactions of Neurotransmitter Transporters in the Postgenomic Era

被引：25

作者：

Omote, Hiroshi ^{[1
]}

Miyaji, Takaaki ^{[2
]}

Hiasa, Miki ^{[1
]}

Juge, Narinobu ^{[2
]}

Moriyama, Yoshinori ^{[1
,2
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Membrane Biochem, Okayama 7008530, Japan

[2] Okayama Univ, Adv Sci Res Ctr, Okayama 7008530, Japan

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 56 | 2016年 / 56卷

关键词：

reconstitution; transporter; purification; vesicular neurotransmitter transporter; SLC17; VESICULAR GLUTAMATE TRANSPORTER; DEPENDENT PHOSPHATE TRANSPORTER; SYNAPTIC VESICLES; ATP RELEASE; CHROMAFFIN GRANULES; L-ASPARTATE; CHLORIDE CONDUCTANCE; EXOCYTOTIC RELEASE; ACID-TRANSPORT; STORAGE;

D O I：

10.1146/annurev-pharmtox-010814-124816

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Vesicular neurotransmitter transporters are responsible for the accumulation of neurotransmitters in secretory vesicles and play essential roles in chemical transmission. The SLC17 family contributes to sequestration of anionic neurotransmitters such as glutamate, aspartate, and nucleotides. Identification and subsequent cellular and molecular biological studies of SLC17 transporters unveiled the principles underlying the actions of these transporters. Recent progress in reconstitution methods in combination with postgenomic approaches has advanced studies on neurotransmitter transporters. This review summarizes the molecular properties of SLC17-type transporters and recent findings regarding the novel SLC18 transporter.

引用

页码：385 / 402

页数：18

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