A new alkaloid from Portulaca oleracea L. and its antiacetylcholinesterase activity

被引：47
|
作者：
Xiu, Fen [1 ]
Li, Xuetao [1 ]
Zhang, Wenjie [1 ]
He, Fan [1 ]
Ying, Xixiang [1 ]
Stien, Didier [2 ]
机构：
[1] Liaoning Univ Tradit Chinese Med, Sch Pharm, Dalian, Peoples R China
[2] UPMC Univ Paris 06, Sorbonne Univ, CNRS, LBBM,Observ Oceanol, Banyuls Sur Mer, France
来源：
NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 18期
基金：
中国国家自然科学基金;
关键词：
Portulaca oleracea L; alkaloid; NMR; anticholinesterase activity; ANTIOXIDANT; AMIDES;
D O I：
10.1080/14786419.2018.1460833
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new alkaloid, (10E, 12E)-9-ureidooctadeca-10, 12-dienoic acid, named oleraurea (1) and 10 known compounds, p-hydroxybenzaldehyde (2), p-hydroxybenzoic acid (3), p-hydroxyacetophenone (4), benzamide (5), (E)-p-coumaramide (6), (E)-ferulamide (7), soyalkaloid A (8), beta-carboline-3-carboxylic acid (9), 2, 3, 4, 9-tetrahydro-1H-pyrido [3, 4-b] indole-3-carboxylic acid (10), (1S, 3S)-1-methyl-1, 2, 3, 4-tetrahydro-beta-carboline-3-carboxylic acid (11) were obtained from Portulaca oleracea L., in which, compounds 4, 5, 8-11 were isolated from the plant for the first time. The structure of the compound 1 was identified using spectroscopic methods including 1D and 2D NMR, HR-ESI-TOF-MS. The compounds 1, 5-11 presented anticholinesterase activities, but the P. oleracea extract (POE) presented very low anticholinesterase activity. [GRAPHICS] .
引用
收藏
页码：2583 / 2590
页数：8
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