Synthesis of (-)-dysiherbaine

被引：70

作者：

Snider, BB ^{[1
]}

Hawryluk, NA ^{[1
]}

机构：

[1] Brandeis Univ, Dept Chem MS015, Waltham, MA 02454 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 05期

关键词：

D O I：

10.1021/ol991393d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The first synthesis of (-)-dysiherbaine has been accomplished using intramolecular S(N)2 substitutions of a carbamate anion on an epoxide and an alkoxide on a secondary mesylate to efficiently construct the bicyclic skeleton stereospecifically from xylose, A general sequence has been developed to introduce an allyl group and convert it to the alanine side chain that should be useful for the construction of dysiherbaine analogues.

引用

页码：635 / 638

页数：4

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